Reduction by cycloheximide of lysosomal proteolytic enzyme activity and rate of protein degradation in organ-cultured hearts

Kern Wildenthal, Edmond E. Griffin

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Cycloheximide, an agent whose primary action is inhibition of protein synthesis, also causes a decrease in the rate of protein degradation in cultured fetal mouse hearts. This is associated with marked decreases in the activities of cathespin D and other lysosomal hydrolases. It is suggested that reduced lysosomal proteolytic capacity may contribute to cycloheximide-induced inhibition of protein degradation.

Original languageEnglish (US)
Pages (from-to)519-524
Number of pages6
JournalBBA - General Subjects
Volume444
Issue number2
DOIs
StatePublished - Sep 24 1976

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology

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