Reduction in cardiovascular risk factors with intensive diabetes treatment in insulin-dependent diabetes mellitus

J. Rosenstock, S. Strowig, S. Cercone, Philip Raskin

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

We measured plasma lipid and lipoprotein levels at baseline and at 6-mo intervals in 47 normolipidemic patients with classic insulin-dependent diabetes mellitus treated either with a conventional (n = 21) or intensive (n = 26) diabetes-treatment program. Patients were followed for a mean of 3 yr (range 1-4 yr). Intensive diabetes treatment resulted in a significant improvement in glycemic control that caused sustained changes in plasma lipid and lipoprotein levels that were not evident with the conventional-treatment program. These changes, which persisted for periods averaging 3 yr, can potentially reduce predicted risk for the development of premature atherosclerosis. Thus, long-term near normoglycemia may have a role in the prevention of atherosclerosis in insulin-dependent diabetic patients.

Original languageEnglish (US)
Pages (from-to)729-734
Number of pages6
JournalDiabetes care
Volume10
Issue number6
DOIs
StatePublished - Jan 1 1987

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

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