TY - JOUR
T1 - Reduction in intestinal calcium absorption by hydrochlorothiazide in postmenopausal osteoporosis
AU - Sakhaee, K.
AU - Nicar, M. J.
AU - Glass, K.
AU - Zerwekh, J. E.
AU - Pak, C. Y.
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1984/12
Y1 - 1984/12
N2 - In six women with postmenopausal osteoporosis, most of whom responded to 50 μg/day 25-hydroxyvitamin D (25-OHD) therapy with a rise in intestinal calcium (Ca) absorption, 50 mg/day hydrochlorothiazide (TZ) were added to determine whether the resulting decline in urinary Ca would cause Ca retention in the skeleton. Urinary Ca decreased from 183 ± 48 (SD) mg/day to 142 ± 67 mg/day (P < 0.05) when TZ was added. However, fractional Ca absorption also declined from 0.532 ± 0.077 during 25-OHD treatment to 0.401 ± 0.064 during combined 25-OHD and TZ therapy (P < 0.0025). The above changes were accompanied by a significant decline in urinary cAMP from 4.29 ± 1.64 to 3.19 ± 1.44 μmol/g creatinine (P < 0.05) and in serum 1,25-dihydroxyvitamin D from 41 ± 14 to 22 ± 11 pg/ml (P < 0.01). The results suggest that TZ lowers urinary Ca, suppresses parathyroid function, inhibits 1,25-dihydroxyvitamin D synthesis, and thereby reduces intestinal Ca absorption. Thus, combined 25-OHD and TZ therapy probably does not improve Ca balance.
AB - In six women with postmenopausal osteoporosis, most of whom responded to 50 μg/day 25-hydroxyvitamin D (25-OHD) therapy with a rise in intestinal calcium (Ca) absorption, 50 mg/day hydrochlorothiazide (TZ) were added to determine whether the resulting decline in urinary Ca would cause Ca retention in the skeleton. Urinary Ca decreased from 183 ± 48 (SD) mg/day to 142 ± 67 mg/day (P < 0.05) when TZ was added. However, fractional Ca absorption also declined from 0.532 ± 0.077 during 25-OHD treatment to 0.401 ± 0.064 during combined 25-OHD and TZ therapy (P < 0.0025). The above changes were accompanied by a significant decline in urinary cAMP from 4.29 ± 1.64 to 3.19 ± 1.44 μmol/g creatinine (P < 0.05) and in serum 1,25-dihydroxyvitamin D from 41 ± 14 to 22 ± 11 pg/ml (P < 0.01). The results suggest that TZ lowers urinary Ca, suppresses parathyroid function, inhibits 1,25-dihydroxyvitamin D synthesis, and thereby reduces intestinal Ca absorption. Thus, combined 25-OHD and TZ therapy probably does not improve Ca balance.
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U2 - 10.1210/jcem-59-6-1037
DO - 10.1210/jcem-59-6-1037
M3 - Article
C2 - 6490791
AN - SCOPUS:0021686268
VL - 59
SP - 1037
EP - 1043
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 6
ER -