Reduction of Carbonyl Function to a Methyl Group

Gan B. Bajracharya, Tsutomu Nogami, Tienan Jin, Kumiko Matsuda, Vladimir Gevorgyan, Yoshinori Yamamoto

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

A direct exhaustive reduction of aliphatic carbonyl functions (aldehydes, acyl chlorides, esters and carboxylic acids) to a methyl group by triethylsilane (Et3SiH) in the presence of catalytic amount of tris(pentafluorophenyl)borane [B(C6F5)3] is described. Aromatic carbonyl functions could undergo partial reduction to the corresponding TES-protected benzylic alcohols.

Original languageEnglish (US)
Pages (from-to)308-311
Number of pages4
JournalSynthesis
Issue number2
DOIs
StatePublished - Feb 2 2004
Externally publishedYes

Keywords

  • Acyl chlorides
  • Aldehydes
  • Carboxylic acids
  • Esters
  • Reductions

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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    Bajracharya, G. B., Nogami, T., Jin, T., Matsuda, K., Gevorgyan, V., & Yamamoto, Y. (2004). Reduction of Carbonyl Function to a Methyl Group. Synthesis, (2), 308-311. https://doi.org/10.1055/s-2003-44356