Reduction of cerebellar volume in major depression: A controlled MRI study

P. Rodrigo Escalona, Bridget Early, William M. McDonald, P. Murali Doraiswamy, Sunjay A. Shah, Mustafa M. Husain, Orest B. Boyko, Gary S. Figiel, Everett H. Ellinwood, Charles B. Nemeroff, K. Ranga R Krishnan

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

A systematic sampling stereological method of serially acquired axial intermediate T2‐weighted Spin echo magnetic resonance imaging (MRI) of the brain was used to measure cerebellar volume in 30 patients who fulfilled DSM III criteria for major depression and compared with 35 normal controls. The mean cerebellar volume of depressed patients was significantly smaller than the controls. This preliminary study adds new evidence for the possible participation of the cerebellum in the pathophysiology of major depression and warrants further investigation in this area. Depression 1:156–158 (1993). © 1993 Wiley‐Liss, Inc.

Original languageEnglish (US)
Pages (from-to)156-158
Number of pages3
JournalDepression
Volume1
Issue number3
DOIs
StatePublished - 1993

Keywords

  • cerebellum
  • magnetic resonance imaging
  • major depression

ASJC Scopus subject areas

  • Psychiatry and Mental health

Fingerprint Dive into the research topics of 'Reduction of cerebellar volume in major depression: A controlled MRI study'. Together they form a unique fingerprint.

  • Cite this

    Escalona, P. R., Early, B., McDonald, W. M., Doraiswamy, P. M., Shah, S. A., Husain, M. M., Boyko, O. B., Figiel, G. S., Ellinwood, E. H., Nemeroff, C. B., & Krishnan, K. R. R. (1993). Reduction of cerebellar volume in major depression: A controlled MRI study. Depression, 1(3), 156-158. https://doi.org/10.1002/depr.3050010307