Reduction of corpus callosum growth after severe traumatic brain injury in children

Harvey S. Levin, D. A. Benavidez, K. Verger-Maestre, N. Perachio, J. Song, D. B. Mendelsohn, J. M. Fletcher

Research output: Contribution to journalArticlepeer-review

89 Scopus citations


Objective: To study effects of closed head injury (CHI) severity on development of corpus callosum (CC) in children, using MRI. Background: Vulnerability of CC to diffuse axonal injury has been shown in adults and children by neuropathologic and MRI studies. Given continued development of CC through the second decade, serial MRI could characterize effects of CHI on CC growth in children. Methods: MRI performed at 3 and 36 months after severe (mean age = 10.3 years, n = 25) and mild to moderate (mean age = 9.7 years, n = 28) CHI. Mild to moderate and severe CHI groups did not differ in demographic features. Morphometry of T1-weighted midsagittal CC by two operators with satisfactory interrater reliability yielded uncorrected and corrected CC volume. Results: An interaction of occasion with CHI severity was present as CC area decreased from 3 to 36 months in severely injured children and increased in the mild to moderate CHI group. Uncorrected CC area was correlated with acute CHI severity and functional outcome at 36 months postinjury. Conclusions: Morphometric measurement of CC area provides a useful index of diffuse injury, which is related to functional outcome of CHI in children.

Original languageEnglish (US)
Pages (from-to)647-653
Number of pages7
Issue number3
StatePublished - Feb 8 2000


  • Children
  • Corpus callosum
  • Traumatic brain injury

ASJC Scopus subject areas

  • Clinical Neurology


Dive into the research topics of 'Reduction of corpus callosum growth after severe traumatic brain injury in children'. Together they form a unique fingerprint.

Cite this