Reduction of femoral arterial bleeding post catheterization using percutaneous application of fibrin sealant

S. Ismail, M. J. Combs, N. C. Goodman, S. S. Teotia, C. D. Teates, R. D. Abbott, R. E. Fechner, S. P. Nolan, E. R. Powers, W. D. Spotnitz

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

The number of cardiac catheterizations performed yearly is growing with correspondingly increasing amounts of morbidity, complications, and hospital costs. This study suggests that fibrin sealant instillation via an arterial sheath at the completion of femoral catheterization may improve hemostasis. Results using fibrin sealant in 12 unheparinized dogs documented significant reductions (McNemar's exact test) versus control for groin ecchymoses (1 versus 8, P = .008) and radiolabeled hematoma formation (0 versus 7, P = .016). Also swelling was less in the fibrin sealant treated groins when compared to control groins (1 versus 6, P = .125), but failed to reach statistical significance. Results in eight heparinized dogs (activated clotting time 374 ± 22, mean ± SEM) revealed a statistically significant reduction in signs of gross bleeding in the fibrin sealant‐treated groins (1 versus 8, P = .016). This method may contribute to reduced morbidity, complications, and length of hospitalization. It may also allow for earlier patient mobilization after cardiac catheterization.

Original languageEnglish (US)
Pages (from-to)88-95
Number of pages8
JournalCatheterization and Cardiovascular Diagnosis
Volume34
Issue number1
DOIs
StatePublished - Jan 1995

    Fingerprint

Keywords

  • groin
  • hemostasis
  • percutaneous
  • tissue adhesive

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Ismail, S., Combs, M. J., Goodman, N. C., Teotia, S. S., Teates, C. D., Abbott, R. D., Fechner, R. E., Nolan, S. P., Powers, E. R., & Spotnitz, W. D. (1995). Reduction of femoral arterial bleeding post catheterization using percutaneous application of fibrin sealant. Catheterization and Cardiovascular Diagnosis, 34(1), 88-95. https://doi.org/10.1002/ccd.1810340322