Reduction of hippocampal-kindled seizure activity in rats by stereotactic radiosurgery

Bomin Sun, Antonio A F DeSalles, Paul M. Medin, Timothy D. Solberg, Brett Hoebel, Mark Felder-Allen, Scott E. Krahl, Robert F. Ackermann

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Radiosurgery may provide an alternative therapy for intractable epilepsy by eliminating or modifying abnormally active pacemaker neurons in epileptic loci. In the present study, the effect of radiosurgery on rat hippocampal kindling was examined. Rats received daily hippocampal stimulus trains until they were fully kindled. They then underwent radiosurgery of the kindled focus, receiving a single-dose of 0-, 10-, or 40-Gy. The 40-Gy group demonstrated an acute decrease in seizure threshold (3-5 days). Three months after radiosurgery, the threshold for seizures increased and the duration of afterdischarges decreased in the 40-Gy radiosurgery group compared to controls. The changes to both seizure threshold and afterdischarge duration were not significant in the 10-Gy group. These data suggest that radiosurgery is an effective means of reducing the epileptogenic activity of seizure foci.

Original languageEnglish (US)
Pages (from-to)691-695
Number of pages5
JournalExperimental Neurology
Volume154
Issue number2
DOIs
StatePublished - Dec 1998

Keywords

  • Epilepsy
  • Hippocampus
  • Kindling
  • Radiosurgery
  • Rats

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

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    Sun, B., DeSalles, A. A. F., Medin, P. M., Solberg, T. D., Hoebel, B., Felder-Allen, M., Krahl, S. E., & Ackermann, R. F. (1998). Reduction of hippocampal-kindled seizure activity in rats by stereotactic radiosurgery. Experimental Neurology, 154(2), 691-695. https://doi.org/10.1006/exnr.1998.6935