Reduction of hippocampal-kindled seizure activity in rats by stereotactic radiosurgery

Bomin Sun; Antonio A F DeSalles; Paul M. Medin; Timothy D. Solberg; Brett Hoebel; Mark Felder-Allen; Scott E. Krahl; Robert F. Ackermann

doi:10.1006/exnr.1998.6935

Reduction of hippocampal-kindled seizure activity in rats by stereotactic radiosurgery

Bomin Sun, Antonio A F DeSalles, Paul M. Medin, Timothy D. Solberg, Brett Hoebel, Mark Felder-Allen, Scott E. Krahl, Robert F. Ackermann

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Radiosurgery may provide an alternative therapy for intractable epilepsy by eliminating or modifying abnormally active pacemaker neurons in epileptic loci. In the present study, the effect of radiosurgery on rat hippocampal kindling was examined. Rats received daily hippocampal stimulus trains until they were fully kindled. They then underwent radiosurgery of the kindled focus, receiving a single-dose of 0-, 10-, or 40-Gy. The 40-Gy group demonstrated an acute decrease in seizure threshold (3-5 days). Three months after radiosurgery, the threshold for seizures increased and the duration of afterdischarges decreased in the 40-Gy radiosurgery group compared to controls. The changes to both seizure threshold and afterdischarge duration were not significant in the 10-Gy group. These data suggest that radiosurgery is an effective means of reducing the epileptogenic activity of seizure foci.

Original language	English (US)
Pages (from-to)	691-695
Number of pages	5
Journal	Experimental Neurology
Volume	154
Issue number	2
DOIs	https://doi.org/10.1006/exnr.1998.6935
State	Published - Dec 1998

Keywords

Epilepsy
Hippocampus
Kindling
Radiosurgery
Rats

ASJC Scopus subject areas

Neurology
Developmental Neuroscience

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10.1006/exnr.1998.6935

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title = "Reduction of hippocampal-kindled seizure activity in rats by stereotactic radiosurgery",

abstract = "Radiosurgery may provide an alternative therapy for intractable epilepsy by eliminating or modifying abnormally active pacemaker neurons in epileptic loci. In the present study, the effect of radiosurgery on rat hippocampal kindling was examined. Rats received daily hippocampal stimulus trains until they were fully kindled. They then underwent radiosurgery of the kindled focus, receiving a single-dose of 0-, 10-, or 40-Gy. The 40-Gy group demonstrated an acute decrease in seizure threshold (3-5 days). Three months after radiosurgery, the threshold for seizures increased and the duration of afterdischarges decreased in the 40-Gy radiosurgery group compared to controls. The changes to both seizure threshold and afterdischarge duration were not significant in the 10-Gy group. These data suggest that radiosurgery is an effective means of reducing the epileptogenic activity of seizure foci.",

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AU - DeSalles, Antonio A F

AU - Medin, Paul M.

AU - Solberg, Timothy D.

AU - Hoebel, Brett

AU - Felder-Allen, Mark

AU - Krahl, Scott E.

AU - Ackermann, Robert F.

PY - 1998/12

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AB - Radiosurgery may provide an alternative therapy for intractable epilepsy by eliminating or modifying abnormally active pacemaker neurons in epileptic loci. In the present study, the effect of radiosurgery on rat hippocampal kindling was examined. Rats received daily hippocampal stimulus trains until they were fully kindled. They then underwent radiosurgery of the kindled focus, receiving a single-dose of 0-, 10-, or 40-Gy. The 40-Gy group demonstrated an acute decrease in seizure threshold (3-5 days). Three months after radiosurgery, the threshold for seizures increased and the duration of afterdischarges decreased in the 40-Gy radiosurgery group compared to controls. The changes to both seizure threshold and afterdischarge duration were not significant in the 10-Gy group. These data suggest that radiosurgery is an effective means of reducing the epileptogenic activity of seizure foci.

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KW - Hippocampus

KW - Kindling

KW - Radiosurgery

KW - Rats

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Reduction of hippocampal-kindled seizure activity in rats by stereotactic radiosurgery

Abstract

Keywords

ASJC Scopus subject areas

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