Reduction of new coronary events and new atherothrombotic brain infarction in older persons with diabetes mellitus, prior myocardial infarction, and serum low-density lipoprotein cholesterol ≥125 mg/dl treated with statins

Wilbert S. Aronow, Chul Ahn, Hal Gutstein

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Background. We report the incidence of new coronary events and new atherothrombotic brain infarction (ABI) in older men and women with diabetes mellitus, prior myocardial infarction, and a serum low-density lipoprotein (LDL) cholesterol of ≥125 mg/dl treated with statins and with no lipid-lowering drug. Methods. The incidence of new coronary events and of new ABI was investigated in an observational prospective study of 529 diabetics, mean age 79 ± 9 years, with prior myocardial infarction and a serum LDL cholesterol of ≥125 mg/dl treated with statins (279 persons or 53%) and no lipid-lowering drug (250 persons or 47%). Follow-up was 29 ± 18 months. Results. At follow-up, the stepwise Cox regression model showed that after controlling for other risk factors, the use of statins was associated with a 37% significant independent reduction in the incidence of new coronary events and with a 47% significant independent reduction in the incidence of new ABI. Conclusions. Use of statins was associated with a 37% significant, independent reduction in new coronary events and a 47% significant, independent reduction in new ABI in older men and women with diabetes mellitus, prior myocardial infarction, and a serum LDL cholesterol of ≥125 mg/dl. Elderly diabetics with prior myocardial infarction and increased serum LDL cholesterol should especially be treated with statins.

Original languageEnglish (US)
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume57
Issue number11
StatePublished - Nov 1 2002

Fingerprint

Brain Infarction
Hydroxymethylglutaryl-CoA Reductase Inhibitors
LDL Cholesterol
Diabetes Mellitus
Myocardial Infarction
Serum
Incidence
Lipids
Proportional Hazards Models
Pharmaceutical Preparations
Observational Studies
Prospective Studies

ASJC Scopus subject areas

  • Aging

Cite this

@article{45804c3b54704347865071f1aea8037b,
title = "Reduction of new coronary events and new atherothrombotic brain infarction in older persons with diabetes mellitus, prior myocardial infarction, and serum low-density lipoprotein cholesterol ≥125 mg/dl treated with statins",
abstract = "Background. We report the incidence of new coronary events and new atherothrombotic brain infarction (ABI) in older men and women with diabetes mellitus, prior myocardial infarction, and a serum low-density lipoprotein (LDL) cholesterol of ≥125 mg/dl treated with statins and with no lipid-lowering drug. Methods. The incidence of new coronary events and of new ABI was investigated in an observational prospective study of 529 diabetics, mean age 79 ± 9 years, with prior myocardial infarction and a serum LDL cholesterol of ≥125 mg/dl treated with statins (279 persons or 53{\%}) and no lipid-lowering drug (250 persons or 47{\%}). Follow-up was 29 ± 18 months. Results. At follow-up, the stepwise Cox regression model showed that after controlling for other risk factors, the use of statins was associated with a 37{\%} significant independent reduction in the incidence of new coronary events and with a 47{\%} significant independent reduction in the incidence of new ABI. Conclusions. Use of statins was associated with a 37{\%} significant, independent reduction in new coronary events and a 47{\%} significant, independent reduction in new ABI in older men and women with diabetes mellitus, prior myocardial infarction, and a serum LDL cholesterol of ≥125 mg/dl. Elderly diabetics with prior myocardial infarction and increased serum LDL cholesterol should especially be treated with statins.",
author = "Aronow, {Wilbert S.} and Chul Ahn and Hal Gutstein",
year = "2002",
month = "11",
day = "1",
language = "English (US)",
volume = "57",
journal = "Journals of Gerontology - Series A Biological Sciences and Medical Sciences",
issn = "1079-5006",
publisher = "Oxford University Press",
number = "11",

}

TY - JOUR

T1 - Reduction of new coronary events and new atherothrombotic brain infarction in older persons with diabetes mellitus, prior myocardial infarction, and serum low-density lipoprotein cholesterol ≥125 mg/dl treated with statins

AU - Aronow, Wilbert S.

AU - Ahn, Chul

AU - Gutstein, Hal

PY - 2002/11/1

Y1 - 2002/11/1

N2 - Background. We report the incidence of new coronary events and new atherothrombotic brain infarction (ABI) in older men and women with diabetes mellitus, prior myocardial infarction, and a serum low-density lipoprotein (LDL) cholesterol of ≥125 mg/dl treated with statins and with no lipid-lowering drug. Methods. The incidence of new coronary events and of new ABI was investigated in an observational prospective study of 529 diabetics, mean age 79 ± 9 years, with prior myocardial infarction and a serum LDL cholesterol of ≥125 mg/dl treated with statins (279 persons or 53%) and no lipid-lowering drug (250 persons or 47%). Follow-up was 29 ± 18 months. Results. At follow-up, the stepwise Cox regression model showed that after controlling for other risk factors, the use of statins was associated with a 37% significant independent reduction in the incidence of new coronary events and with a 47% significant independent reduction in the incidence of new ABI. Conclusions. Use of statins was associated with a 37% significant, independent reduction in new coronary events and a 47% significant, independent reduction in new ABI in older men and women with diabetes mellitus, prior myocardial infarction, and a serum LDL cholesterol of ≥125 mg/dl. Elderly diabetics with prior myocardial infarction and increased serum LDL cholesterol should especially be treated with statins.

AB - Background. We report the incidence of new coronary events and new atherothrombotic brain infarction (ABI) in older men and women with diabetes mellitus, prior myocardial infarction, and a serum low-density lipoprotein (LDL) cholesterol of ≥125 mg/dl treated with statins and with no lipid-lowering drug. Methods. The incidence of new coronary events and of new ABI was investigated in an observational prospective study of 529 diabetics, mean age 79 ± 9 years, with prior myocardial infarction and a serum LDL cholesterol of ≥125 mg/dl treated with statins (279 persons or 53%) and no lipid-lowering drug (250 persons or 47%). Follow-up was 29 ± 18 months. Results. At follow-up, the stepwise Cox regression model showed that after controlling for other risk factors, the use of statins was associated with a 37% significant independent reduction in the incidence of new coronary events and with a 47% significant independent reduction in the incidence of new ABI. Conclusions. Use of statins was associated with a 37% significant, independent reduction in new coronary events and a 47% significant, independent reduction in new ABI in older men and women with diabetes mellitus, prior myocardial infarction, and a serum LDL cholesterol of ≥125 mg/dl. Elderly diabetics with prior myocardial infarction and increased serum LDL cholesterol should especially be treated with statins.

UR - http://www.scopus.com/inward/record.url?scp=0036845594&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036845594&partnerID=8YFLogxK

M3 - Article

VL - 57

JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

SN - 1079-5006

IS - 11

ER -