Redundant control of adipogenesis by histone deacetylases 1 and 2

Michael Haberland, Michele Carrer, Mayssa H. Mokalled, Rusty L. Montgomery, Eric N. Olson

Research output: Contribution to journalArticle

81 Scopus citations

Abstract

Adipocyte differentiation is a well defined process that is under the control of transcriptional activators and repressors. Weshow that histone deacetylase (HDAC) inhibitors efficiently block adipocyte differentiation in vitro. This effect is specific to adipogenesis, as another mesenchymal differentiation process, osteoblastogenesis, is enhanced upon HDAC inhibition. Through the systematic genetic deletion of HDAC genes in cultured mesenchymal precursor cells, we show that deletion of HDAC1 and HDAC2 leads to reduced lipid accumulation, revealing redundant and requisite roles of these class I HDACs in adipogenesis. These findings unveil a previously unrecognized role for HDACs in the control of adipogenesis.

Original languageEnglish (US)
Pages (from-to)14663-14670
Number of pages8
JournalJournal of Biological Chemistry
Volume285
Issue number19
DOIs
StatePublished - May 7 2010

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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