Abstract
Reelin is a glycoprotein that is critical for proper layering of neocortex during development as well as dynamic regulation of glutamatergic postsynaptic signaling in mature synapses. Here, we show that Reelin also acts presynaptically, resulting in robust rapid enhancement of spontaneous neurotransmitter release without affecting properties of evoked neurotransmission. This effect of Reelin requires a modest but significant increase in presynaptic Ca2+ initiatedvia ApoER2 signaling. The specificity of Reelin actionon spontaneous neurotransmitter release is encodedat the level of vesicular SNARE machinery as it requires VAMP7 and SNAP-25 but not synaptobrevin2, VAMP4, or vti1a. These results uncover a presynaptic regulatory pathway that utilizes the heterogeneity ofsynaptic vesicle-associated SNAREs and selectively augments action potential-independent neurotransmission
Original language | English (US) |
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Pages (from-to) | 934-946 |
Number of pages | 13 |
Journal | Neuron |
Volume | 80 |
Issue number | 4 |
DOIs | |
State | Published - Nov 20 2013 |
ASJC Scopus subject areas
- General Neuroscience