Reflex control of glucoregulatory exercise responses by group III and IV muscle afferents

J. Vissing, G. A. Iwamoto, I. E. Fuchs, H. Galbo, J. H. Mitchell

Research output: Contribution to journalArticle

Abstract

Group III and IV muscle afferents are active during exercise and relay information from mechano- and metaboreceptors in muscle. We hypothesized that these afferents participate in the regulation of endocrine and metabolic adjustments to exercise. Muscle branches of the femoral nerves were electrically stimulated in 10 anesthetized and paralyzed cats at 3, 20, and 140 times motor threshold, for 10 min at each intensity, recruiting group III afferents at 20 times motor threshold and group III and IV afferents at 140 times motor threshold. Six cats were not stimulated but were otherwise treated as stimulated cats. [3-3H]glucose was infused intravenously, and arterial blood was sampled for analysis of substrates and hormones. Three times motor threshold stimulation induced no changes in measured metabolic parameters. Twenty times motor threshold stimulation elicited increases (P < 0.05 vs. control) in glucose production (8.2 ± 1.8 μmol · min-1 · kg- 1) and plasma glucose (0.29 ± 0.07 mmol/l) and adrenocorticotropic hormone (ACTH; 35 ± 12 pg/ml). Stimulation at 140 times motor threshold elicited increases (P < 0.05 vs. control) in glucose production (10.2 ± 5.4 μmol · min-1 · kg-1), plasma glucose (0.53 ± 0.10 mmol/l), ACTH (94 ± 28 pg/ml), β-endorphin (17 ± 6 pg/ml), and Met-enkephalin (15 ± 2 pg/ml) and decreases (P < 0.05 vs. control) in insulin (0.65 ± 0.14 μU/ml). Glycerol and glucagon did not change with stimulations. The findings provide evidence for a reflex control from muscle of hormone secretion and mobilization of glucose during exercise.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume266
Issue number3 35-3
StatePublished - 1994

Fingerprint

Reflex
Glucose
Muscles
Adrenocorticotropic Hormone
Cats
Hormones
Endorphins
Femoral Nerve
Methionine Enkephalin
Mechanoreceptors
Glucagon
Glycerol
Insulin

Keywords

  • β-endorphin
  • adrenocorticotropic hormone
  • cat
  • femoral nerve stimulation
  • glucose homeostasis
  • insulin
  • methionine enkephalin

ASJC Scopus subject areas

  • Physiology

Cite this

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title = "Reflex control of glucoregulatory exercise responses by group III and IV muscle afferents",
abstract = "Group III and IV muscle afferents are active during exercise and relay information from mechano- and metaboreceptors in muscle. We hypothesized that these afferents participate in the regulation of endocrine and metabolic adjustments to exercise. Muscle branches of the femoral nerves were electrically stimulated in 10 anesthetized and paralyzed cats at 3, 20, and 140 times motor threshold, for 10 min at each intensity, recruiting group III afferents at 20 times motor threshold and group III and IV afferents at 140 times motor threshold. Six cats were not stimulated but were otherwise treated as stimulated cats. [3-3H]glucose was infused intravenously, and arterial blood was sampled for analysis of substrates and hormones. Three times motor threshold stimulation induced no changes in measured metabolic parameters. Twenty times motor threshold stimulation elicited increases (P < 0.05 vs. control) in glucose production (8.2 ± 1.8 μmol · min-1 · kg- 1) and plasma glucose (0.29 ± 0.07 mmol/l) and adrenocorticotropic hormone (ACTH; 35 ± 12 pg/ml). Stimulation at 140 times motor threshold elicited increases (P < 0.05 vs. control) in glucose production (10.2 ± 5.4 μmol · min-1 · kg-1), plasma glucose (0.53 ± 0.10 mmol/l), ACTH (94 ± 28 pg/ml), β-endorphin (17 ± 6 pg/ml), and Met-enkephalin (15 ± 2 pg/ml) and decreases (P < 0.05 vs. control) in insulin (0.65 ± 0.14 μU/ml). Glycerol and glucagon did not change with stimulations. The findings provide evidence for a reflex control from muscle of hormone secretion and mobilization of glucose during exercise.",
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T1 - Reflex control of glucoregulatory exercise responses by group III and IV muscle afferents

AU - Vissing, J.

AU - Iwamoto, G. A.

AU - Fuchs, I. E.

AU - Galbo, H.

AU - Mitchell, J. H.

PY - 1994

Y1 - 1994

N2 - Group III and IV muscle afferents are active during exercise and relay information from mechano- and metaboreceptors in muscle. We hypothesized that these afferents participate in the regulation of endocrine and metabolic adjustments to exercise. Muscle branches of the femoral nerves were electrically stimulated in 10 anesthetized and paralyzed cats at 3, 20, and 140 times motor threshold, for 10 min at each intensity, recruiting group III afferents at 20 times motor threshold and group III and IV afferents at 140 times motor threshold. Six cats were not stimulated but were otherwise treated as stimulated cats. [3-3H]glucose was infused intravenously, and arterial blood was sampled for analysis of substrates and hormones. Three times motor threshold stimulation induced no changes in measured metabolic parameters. Twenty times motor threshold stimulation elicited increases (P < 0.05 vs. control) in glucose production (8.2 ± 1.8 μmol · min-1 · kg- 1) and plasma glucose (0.29 ± 0.07 mmol/l) and adrenocorticotropic hormone (ACTH; 35 ± 12 pg/ml). Stimulation at 140 times motor threshold elicited increases (P < 0.05 vs. control) in glucose production (10.2 ± 5.4 μmol · min-1 · kg-1), plasma glucose (0.53 ± 0.10 mmol/l), ACTH (94 ± 28 pg/ml), β-endorphin (17 ± 6 pg/ml), and Met-enkephalin (15 ± 2 pg/ml) and decreases (P < 0.05 vs. control) in insulin (0.65 ± 0.14 μU/ml). Glycerol and glucagon did not change with stimulations. The findings provide evidence for a reflex control from muscle of hormone secretion and mobilization of glucose during exercise.

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KW - glucose homeostasis

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KW - methionine enkephalin

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