Reflex effects on circulation and respiration from contracting skeletal muscle

J. H. Mitchell, W. C. Reardon, D. I. McCloskey

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

Isometric exercise induced by ventral root stimulation in the anesthetized cat caused heart rate (HR) to increase from 199±6 beats/min to 206±6 (P<0.001); mean arterial pressure (MAP) from 99±5.3 mmHg to 112±5.8 (P<0.001); and left ventricular dp/dt at developed pressure of 25 mmHg from 3,960±204 mmHg/s to 4,380±220 (P<0.001), while end-diastolic pressure remained unchanged. Respiratory volume (RV) increased from 755±71 ml/min to 1,160±123 (P<0.001). These changes were abolished by cutting the dorsal roots receiving afferents from the exercising muscle. Beta-adrenergic blockade with propranolol (1 mg/kg) abolished the changes in heart rate and contractile state; however, changes in MAP and RV still occurred. Induced isometric exercise causes a small rise in HR with a more marked increase in MAP, the contractile state of the left ventricle and RV. In this preparation the cardiovascular and respiratory changes reflexly originate from contracting skeletal muscle as proven by section of the corresponding dorsal roots, and the cardiovascular changes are mediated in part by activation of beta-adrenergic receptors in the heart.

Original languageEnglish (US)
Pages (from-to)374-378
Number of pages5
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume2
Issue number3
StatePublished - 1977

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Spinal Nerve Roots
Reflex
Arterial Pressure
Respiration
Skeletal Muscle
Heart Rate
Exercise
Receptors, Adrenergic, beta
Propranolol
Adrenergic Agents
Heart Ventricles
Cats
Blood Pressure
Pressure
Muscles

ASJC Scopus subject areas

  • Physiology

Cite this

Reflex effects on circulation and respiration from contracting skeletal muscle. / Mitchell, J. H.; Reardon, W. C.; McCloskey, D. I.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 2, No. 3, 1977, p. 374-378.

Research output: Contribution to journalArticle

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