Regional cardiac adrenergic function using I-123 meta-iodobenzylguanidine tomographic imaging after acute myocardial infarction

A. Iain McGhie, James R. Corbett, Marvin S. Akers, Padmakur Kulkarni, Michael N. Sills, Mark Kremers, L. Maximilian Buja, Marc Durant-Reville, Robert W. Parkey, James T. Willerson

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120 Scopus citations

Abstract

The effect of acute myocardial infarction (AMI) on regional cardiac adrenergic function was studied in 27 patients mean ± standard deviation 10 ± 4 days after AMI. Regional adrenergk function was evaluated noninvasively with I-123 meta-iodobenzylguanidine (MIBG) using a dedicated 3-detector tomograph. Four hours after its administration, there was reduced MIBG uptake in the region of infarction, 0.38 ± 0.31 counts/pixel/mCi × 103 compared with 0.60 ± 0.30 counts/pixel/mCi × 103 and 0.92 ± 0.35 counts/pixel/mCi × 103 in the zones bordering and distant from the infarct area, respectively, p < 0.001. In all patients, the area of reduced MIBG uptake after 4 hours was more extensive than the associated thallium-201 perfusion defect with defect scores of 52 ± 22 and 23 ± 18%, respectively, p < 0.001. After anterior wall AMI, the 4-hour MIBG defect score was 70 ± 13% and the degree of mismatch between myocardial perfusion and MIBG uptake was 30 ± 9% compared with 39 ± 17 and 21 ± 17% after inferior AMI, p < 0.001 and p = 0.016, respectively. The 4-hour MIBG defect score correlated inversely with the predischarge left ventricular ejection fraction, r = -0.73, p < 0.001. Patients with ventricular arrhythmia of ≥1 ventricular premature complexes per hour, paired ventricular premature complexes or ventricular tachycardia detected during the late hospital phase had higher 4-hour MIBG defect scores, 62.5 ± 15.0%, than patients with no detectable complex ventricular ectopic activity and a ventricular premature complex frequency of <1 per hour, 44.6 ± 23.4%, p = 0.036. These data suggest that after acute AMI in humans (1) the abnormality in adrenergic function is more extensive than the associated abnormality in myocardial perfusion; (2) anterior wall AMI is associated with greater disruption of cardiac adrenergic function than other infarcts; (3) the severity of cardiac adrenergic dysfunction correlates with the degree of left ventricular dysfunction; and (4) the abnormality in regional adrenergic function may be associated with the presence of ventricular ectopic activity after AMI.

Original languageEnglish (US)
Pages (from-to)236-242
Number of pages7
JournalThe American journal of cardiology
Volume67
Issue number4
DOIs
StatePublished - Feb 1 1991

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    McGhie, A. I., Corbett, J. R., Akers, M. S., Kulkarni, P., Sills, M. N., Kremers, M., Buja, L. M., Durant-Reville, M., Parkey, R. W., & Willerson, J. T. (1991). Regional cardiac adrenergic function using I-123 meta-iodobenzylguanidine tomographic imaging after acute myocardial infarction. The American journal of cardiology, 67(4), 236-242. https://doi.org/10.1016/0002-9149(91)90552-V