Regional cerebral blood flow in female cocaine-addicted subjects following limbic activation

Bryon Adinoff, Michael D. Devous, Susan E. Best, Thomas S. Harris, Patricia Chandler, Sylva D. Frock, Mark J. Williams

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Background: Cocaine dependence follows a different disease course in men and women, possibly as a consequence of sex-specific neurobiologic responses to chronic cocaine use. We have previously reported that male cocaine-dependent subjects demonstrate a significantly different limbic response to the limbic-stimulus procaine, as measured by regional cerebral blood flow (rCBF), compared with male controls. In this study, we assessed the limbic rCBF response to procaine in female cocaine-addicted subjects (n=10) and female controls (n=10). Methods: Subjects were administered 1.38 mg/kg procaine or saline intravenously in two separate sessions. Single photon emission computed tomography (SPECT) was used to compare the rCBF response to procaine. Results: Female cocaine-dependent subjects demonstrate a markedly muted, and distinctly different, limbic response to procaine compared with matched healthy controls. Conclusions: The rCBF response to procaine in female cocaine-dependent subjects suggests significant CNS differences compared with non-addicted female controls. Coupled with findings previously observed in male cocaine-dependent subjects, these biologic differences suggest that both male and female subjects experience alterations in limbic responsiveness following the chronic use of cocaine.

Original languageEnglish (US)
Pages (from-to)255-268
Number of pages14
JournalDrug and Alcohol Dependence
Volume71
Issue number3
DOIs
StatePublished - Sep 10 2003

Keywords

  • Cocaine
  • Imaging
  • Limbic system
  • Procaine
  • Single-photon tomography
  • Women

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Regional cerebral blood flow in female cocaine-addicted subjects following limbic activation'. Together they form a unique fingerprint.

  • Cite this

    Adinoff, B., Devous, M. D., Best, S. E., Harris, T. S., Chandler, P., Frock, S. D., & Williams, M. J. (2003). Regional cerebral blood flow in female cocaine-addicted subjects following limbic activation. Drug and Alcohol Dependence, 71(3), 255-268. https://doi.org/10.1016/S0376-8716(03)00138-8