Regional cerebral function and blood flow

Complementary single photon emission computed tomography of the brain using Xenon-133 and [123I]iodoamphetamine

T. R. Simon, M. D. Devous, R. G. Paulman, R. Gregory, R. W. Homan, C. Judd, J. G. Triebel, S. Matthiesen, J. D. Raese, F. J. Bonte

Research output: Contribution to journalArticle

Abstract

Regional cerebral function and blood flow can be imaged using isopropyl[123I]iodoamphetamine (IMP), or 133Xe (DSPECT), respectively. Both of these essentially non-invasive, quantitative, methods are suitable for many nuclear medicine laboratories. This study assessed the in vivo information about intracerebral disease provided by IMP and DSPECT techniques to determine the optimal diagnostic use of these modalities. Single photon emission computed tomograms of 53 subjects were acquired using similar displays for IMP and DSPECT data. Lobar tracer distributions were graded by three experienced observers and analyzed using a kappa statistic to eliminate chance agreements. Overall, both IMP and DSPECT had similar patterns. However, while similar, one or the other technique often displayed abnormalities not present on both. Although technical factors may account for some differences between the modalities, a case of arteriovenous malformation proves that discordant findings can result directly from tracer localization properties. Thus at least some discordances provide truly complementary diagnostic information lacking in either single study taken alone.

Original languageEnglish (US)
Pages (from-to)295-300
Number of pages6
JournalNuclear Medicine and Biology
Volume16
Issue number3
StatePublished - 1989

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Cerebrovascular Circulation
Xenon
Arteriovenous Malformations
Nuclear Medicine
Single-Photon Emission-Computed Tomography
Photons
Brain

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Simon, T. R., Devous, M. D., Paulman, R. G., Gregory, R., Homan, R. W., Judd, C., ... Bonte, F. J. (1989). Regional cerebral function and blood flow: Complementary single photon emission computed tomography of the brain using Xenon-133 and [123I]iodoamphetamine. Nuclear Medicine and Biology, 16(3), 295-300.

Regional cerebral function and blood flow : Complementary single photon emission computed tomography of the brain using Xenon-133 and [123I]iodoamphetamine. / Simon, T. R.; Devous, M. D.; Paulman, R. G.; Gregory, R.; Homan, R. W.; Judd, C.; Triebel, J. G.; Matthiesen, S.; Raese, J. D.; Bonte, F. J.

In: Nuclear Medicine and Biology, Vol. 16, No. 3, 1989, p. 295-300.

Research output: Contribution to journalArticle

Simon, TR, Devous, MD, Paulman, RG, Gregory, R, Homan, RW, Judd, C, Triebel, JG, Matthiesen, S, Raese, JD & Bonte, FJ 1989, 'Regional cerebral function and blood flow: Complementary single photon emission computed tomography of the brain using Xenon-133 and [123I]iodoamphetamine', Nuclear Medicine and Biology, vol. 16, no. 3, pp. 295-300.
Simon, T. R. ; Devous, M. D. ; Paulman, R. G. ; Gregory, R. ; Homan, R. W. ; Judd, C. ; Triebel, J. G. ; Matthiesen, S. ; Raese, J. D. ; Bonte, F. J. / Regional cerebral function and blood flow : Complementary single photon emission computed tomography of the brain using Xenon-133 and [123I]iodoamphetamine. In: Nuclear Medicine and Biology. 1989 ; Vol. 16, No. 3. pp. 295-300.
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