Regional cerebral glucose utilization in chronic organic mental disorders associated with alcoholism

P. R. Martin; D. Rio; B. Adinoff; J. L. Johnson; J. C. Bisserbe; R. R. Rawlings; J. W. Rohrbaugh; J. M. Stapleton; M. J. Eckardt

doi:10.1176/jnp.4.2.159

Regional cerebral glucose utilization in chronic organic mental disorders associated with alcoholism

P. R. Martin, D. Rio, B. Adinoff, J. L. Johnson, J. C. Bisserbe, R. R. Rawlings, J. W. Rohrbaugh, J. M. Stapleton, M. J. Eckardt

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Abstract

Localized cerebral utilization rates for glucose (CMRglu) were determined in 10 detoxified patients with alcoholic organic mental disorders and in 7 age-equivalent normal volunteers using [¹⁸F]2-fluoro-2-deoxyglucose positron emission tomography. Although gray and white matter CMRglu were not significantly different, normalized CMRglu was increased in the left cerebellar and parietal cortical regions and decreased in the right posterior white matter and anterior temporal regions of alcoholic patients, and the pattern of regional CMRglu differed between the two groups. The results suggest functional disruption of right-sided and frontal brain regions and hyperactivity of cerebellar-cortical connections in alcoholic chronic organic mental disorders.

Original language	English (US)
Pages (from-to)	159-167
Number of pages	9
Journal	Journal of Neuropsychiatry and Clinical Neurosciences
Volume	4
Issue number	2
DOIs	https://doi.org/10.1176/jnp.4.2.159
State	Published - 1992

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health

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title = "Regional cerebral glucose utilization in chronic organic mental disorders associated with alcoholism",

abstract = "Localized cerebral utilization rates for glucose (CMRglu) were determined in 10 detoxified patients with alcoholic organic mental disorders and in 7 age-equivalent normal volunteers using [18F]2-fluoro-2-deoxyglucose positron emission tomography. Although gray and white matter CMRglu were not significantly different, normalized CMRglu was increased in the left cerebellar and parietal cortical regions and decreased in the right posterior white matter and anterior temporal regions of alcoholic patients, and the pattern of regional CMRglu differed between the two groups. The results suggest functional disruption of right-sided and frontal brain regions and hyperactivity of cerebellar-cortical connections in alcoholic chronic organic mental disorders.",

author = "Martin, {P. R.} and D. Rio and B. Adinoff and Johnson, {J. L.} and Bisserbe, {J. C.} and Rawlings, {R. R.} and Rohrbaugh, {J. W.} and Stapleton, {J. M.} and Eckardt, {M. J.}",

year = "1992",

doi = "10.1176/jnp.4.2.159",

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T1 - Regional cerebral glucose utilization in chronic organic mental disorders associated with alcoholism

AU - Martin, P. R.

AU - Rio, D.

AU - Adinoff, B.

AU - Johnson, J. L.

AU - Bisserbe, J. C.

AU - Rawlings, R. R.

AU - Rohrbaugh, J. W.

AU - Stapleton, J. M.

AU - Eckardt, M. J.

PY - 1992

Y1 - 1992

N2 - Localized cerebral utilization rates for glucose (CMRglu) were determined in 10 detoxified patients with alcoholic organic mental disorders and in 7 age-equivalent normal volunteers using [18F]2-fluoro-2-deoxyglucose positron emission tomography. Although gray and white matter CMRglu were not significantly different, normalized CMRglu was increased in the left cerebellar and parietal cortical regions and decreased in the right posterior white matter and anterior temporal regions of alcoholic patients, and the pattern of regional CMRglu differed between the two groups. The results suggest functional disruption of right-sided and frontal brain regions and hyperactivity of cerebellar-cortical connections in alcoholic chronic organic mental disorders.

AB - Localized cerebral utilization rates for glucose (CMRglu) were determined in 10 detoxified patients with alcoholic organic mental disorders and in 7 age-equivalent normal volunteers using [18F]2-fluoro-2-deoxyglucose positron emission tomography. Although gray and white matter CMRglu were not significantly different, normalized CMRglu was increased in the left cerebellar and parietal cortical regions and decreased in the right posterior white matter and anterior temporal regions of alcoholic patients, and the pattern of regional CMRglu differed between the two groups. The results suggest functional disruption of right-sided and frontal brain regions and hyperactivity of cerebellar-cortical connections in alcoholic chronic organic mental disorders.

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Regional cerebral glucose utilization in chronic organic mental disorders associated with alcoholism

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