Regional distribution of blood flow of dogs during graded dynamic exercise

T. I. Musch, D. B. Friedman, K. H. Pitetti, G. C. Haidet, J. Stray-Gundersen, J. H. Mitchell, G. A. Ordway

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

The regional blood flow response to progressive treadmill exercise was measured with radioactive microspheres in 25 untrained mongrel dogs. Incremental increases in work intensity resulted in corresponding increases in blood flows to the gracilis, gastrocnemius, semimembranosus, and semitendinosus muscles of the hindlimb and to the heart. During maximal exercise, blood flow was greatest in the semimembranosus muscle and lowest in the semitendinosus muscle (342 and 134 ml-1·100 g tissue-1·min-1, respectively). Exercise produced a decrease in blood flow to the temporalis muscle, which was classified as nonlocomotive in function. Blood flows to the stomach, pancreas, and large intestine decreased at the lowest exercise work load and remained diminished throughout the continuum to maximal exercise. Blood flows to the small intestine and spleen were maintained during submaximal exercise but were reduced by 50% at maximal O2 consumption (V̇O2(max)). No changes in blood flows to the kidneys, adrenal glands, liver, and brain were found. These results demonstrate that 1) renal blood flow is maintained at resting levels during exercise in untrained dogs; 2) blood flow changes in the various organs of the splanchnic region of dogs during exercise are heterogeneous; and 3) blood flows to the working skeletal muscles of dogs progressively increase with increasing work loads up to V̇O2(max).

Original languageEnglish (US)
Pages (from-to)2269-2277
Number of pages9
JournalJournal of Applied Physiology
Volume63
Issue number6
StatePublished - 1987

Fingerprint

Regional Blood Flow
Dogs
Muscles
Workload
Viscera
Renal Circulation
Large Intestine
Hindlimb
Adrenal Glands
Microspheres
Small Intestine
Pancreas
Stomach
Skeletal Muscle
Spleen
Kidney
Hamstring Muscles
Liver
Brain

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Musch, T. I., Friedman, D. B., Pitetti, K. H., Haidet, G. C., Stray-Gundersen, J., Mitchell, J. H., & Ordway, G. A. (1987). Regional distribution of blood flow of dogs during graded dynamic exercise. Journal of Applied Physiology, 63(6), 2269-2277.

Regional distribution of blood flow of dogs during graded dynamic exercise. / Musch, T. I.; Friedman, D. B.; Pitetti, K. H.; Haidet, G. C.; Stray-Gundersen, J.; Mitchell, J. H.; Ordway, G. A.

In: Journal of Applied Physiology, Vol. 63, No. 6, 1987, p. 2269-2277.

Research output: Contribution to journalArticle

Musch, TI, Friedman, DB, Pitetti, KH, Haidet, GC, Stray-Gundersen, J, Mitchell, JH & Ordway, GA 1987, 'Regional distribution of blood flow of dogs during graded dynamic exercise', Journal of Applied Physiology, vol. 63, no. 6, pp. 2269-2277.
Musch TI, Friedman DB, Pitetti KH, Haidet GC, Stray-Gundersen J, Mitchell JH et al. Regional distribution of blood flow of dogs during graded dynamic exercise. Journal of Applied Physiology. 1987;63(6):2269-2277.
Musch, T. I. ; Friedman, D. B. ; Pitetti, K. H. ; Haidet, G. C. ; Stray-Gundersen, J. ; Mitchell, J. H. ; Ordway, G. A. / Regional distribution of blood flow of dogs during graded dynamic exercise. In: Journal of Applied Physiology. 1987 ; Vol. 63, No. 6. pp. 2269-2277.
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