Regional myocardial oxygen tension: 19F MRI of sequestered perfluorocarbon

Himu P. Shukla, Ralph P. Mason, Navin Bansal, Peter P. Antich

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

A novel noninvasive method of measuring local myocardial oxygen tension (pO2) in the perfused rat heart using 19F MRI is demonstrated. Tissue pO2 was determined on the basis of the 19F spin-lattice relaxation rate (R1) of perflubron (perfluorooctyl bromide) sequestered in the heart after IV infusion of an emulsion. Spectroscopic measurement of R1 was previously used to measure a global weighted average of oxygen status. 19F MRI now provides 3D spatial resolution indicating local cardiac pO2 under normally perfused, globally ischemic, and regionally ischemic conditions.

Original languageEnglish (US)
Pages (from-to)827-833
Number of pages7
JournalMagnetic resonance in medicine
Volume35
Issue number6
DOIs
StatePublished - Jun 1996

Keywords

  • Heart
  • MRI
  • Perflubron
  • pO

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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