Regional myocardial oxygen tension: 19F MRI of sequestered perfluorocarbon

Himu P. Shukla; Ralph P. Mason; Navin Bansal; Peter P. Antich

doi:10.1002/mrm.1910350607

Regional myocardial oxygen tension: ¹⁹F MRI of sequestered perfluorocarbon

Himu P. Shukla, Ralph P. Mason, Navin Bansal, Peter P. Antich

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

A novel noninvasive method of measuring local myocardial oxygen tension (pO₂) in the perfused rat heart using ¹⁹F MRI is demonstrated. Tissue pO₂ was determined on the basis of the ¹⁹F spin-lattice relaxation rate (R1) of perflubron (perfluorooctyl bromide) sequestered in the heart after IV infusion of an emulsion. Spectroscopic measurement of R1 was previously used to measure a global weighted average of oxygen status. ¹⁹F MRI now provides 3D spatial resolution indicating local cardiac pO₂ under normally perfused, globally ischemic, and regionally ischemic conditions.

Original language	English (US)
Pages (from-to)	827-833
Number of pages	7
Journal	Magnetic resonance in medicine
Volume	35
Issue number	6
DOIs	https://doi.org/10.1002/mrm.1910350607
State	Published - Jun 1996

Keywords

Heart
MRI
Perflubron
pO

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

Access to Document

10.1002/mrm.1910350607

Cite this

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title = "Regional myocardial oxygen tension: 19F MRI of sequestered perfluorocarbon",

abstract = "A novel noninvasive method of measuring local myocardial oxygen tension (pO2) in the perfused rat heart using 19F MRI is demonstrated. Tissue pO2 was determined on the basis of the 19F spin-lattice relaxation rate (R1) of perflubron (perfluorooctyl bromide) sequestered in the heart after IV infusion of an emulsion. Spectroscopic measurement of R1 was previously used to measure a global weighted average of oxygen status. 19F MRI now provides 3D spatial resolution indicating local cardiac pO2 under normally perfused, globally ischemic, and regionally ischemic conditions.",

keywords = "Heart, MRI, Perflubron, pO",

author = "Shukla, {Himu P.} and Mason, {Ralph P.} and Navin Bansal and Antich, {Peter P.}",

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T2 - 19F MRI of sequestered perfluorocarbon

AU - Shukla, Himu P.

AU - Mason, Ralph P.

AU - Bansal, Navin

AU - Antich, Peter P.

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AB - A novel noninvasive method of measuring local myocardial oxygen tension (pO2) in the perfused rat heart using 19F MRI is demonstrated. Tissue pO2 was determined on the basis of the 19F spin-lattice relaxation rate (R1) of perflubron (perfluorooctyl bromide) sequestered in the heart after IV infusion of an emulsion. Spectroscopic measurement of R1 was previously used to measure a global weighted average of oxygen status. 19F MRI now provides 3D spatial resolution indicating local cardiac pO2 under normally perfused, globally ischemic, and regionally ischemic conditions.

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KW - MRI

KW - Perflubron

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