Regional variation in brain lactate in leigh syndrome by localized 1H magnetic resonance spectroscopy

John A. Detre, Zhiyue Wang, Andrew R. Bogdan, Debra A. Gusnard, Carolyn A. Bay, Peter M. Bingham, Robert A. Zimmerman

Research output: Contribution to journalArticlepeer-review

80 Scopus citations


Localized water‐suppressed 1H magnetic resonance spectroscopy was performed in an 11‐month‐old infant with Leigh syndrome. Spectra obtained from the basal ganglia, occipital cortex, and brainstem showed elevations in lactate, which were most pronounced in regions where abnormalitites were seen with routine T2‐weighted magnetic resonance imaging. This approach has allowed us to examine metabolism in brain tissue directly and noninvasively, and may provide a sensitive means for evaluating metabolic disease and the response to therapy in the brain.

Original languageEnglish (US)
Pages (from-to)218-221
Number of pages4
JournalAnnals of Neurology
Issue number2
StatePublished - Feb 1991

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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