Regional variation in brain lactate in leigh syndrome by localized 1H magnetic resonance spectroscopy

John A. Detre; Zhiyue Wang; Andrew R. Bogdan; Debra A. Gusnard; Carolyn A. Bay; Peter M. Bingham; Robert A. Zimmerman

doi:10.1002/ana.410290219

Regional variation in brain lactate in leigh syndrome by localized ¹H magnetic resonance spectroscopy

John A. Detre, Zhiyue Wang, Andrew R. Bogdan, Debra A. Gusnard, Carolyn A. Bay, Peter M. Bingham, Robert A. Zimmerman

Research output: Contribution to journal › Article › peer-review

91 Scopus citations

Abstract

Localized water‐suppressed ¹H magnetic resonance spectroscopy was performed in an 11‐month‐old infant with Leigh syndrome. Spectra obtained from the basal ganglia, occipital cortex, and brainstem showed elevations in lactate, which were most pronounced in regions where abnormalitites were seen with routine T2‐weighted magnetic resonance imaging. This approach has allowed us to examine metabolism in brain tissue directly and noninvasively, and may provide a sensitive means for evaluating metabolic disease and the response to therapy in the brain.

Original language	English (US)
Pages (from-to)	218-221
Number of pages	4
Journal	Annals of Neurology
Volume	29
Issue number	2
DOIs	https://doi.org/10.1002/ana.410290219
State	Published - Feb 1991

ASJC Scopus subject areas

Neurology
Clinical Neurology

Access to Document

10.1002/ana.410290219

Cite this

@article{0667c100346e450c99e9a0b87901ebb5,

title = "Regional variation in brain lactate in leigh syndrome by localized 1H magnetic resonance spectroscopy",

abstract = "Localized water‐suppressed 1H magnetic resonance spectroscopy was performed in an 11‐month‐old infant with Leigh syndrome. Spectra obtained from the basal ganglia, occipital cortex, and brainstem showed elevations in lactate, which were most pronounced in regions where abnormalitites were seen with routine T2‐weighted magnetic resonance imaging. This approach has allowed us to examine metabolism in brain tissue directly and noninvasively, and may provide a sensitive means for evaluating metabolic disease and the response to therapy in the brain.",

author = "Detre, {John A.} and Zhiyue Wang and Bogdan, {Andrew R.} and Gusnard, {Debra A.} and Bay, {Carolyn A.} and Bingham, {Peter M.} and Zimmerman, {Robert A.}",

year = "1991",

month = feb,

doi = "10.1002/ana.410290219",

language = "English (US)",

volume = "29",

pages = "218--221",

journal = "Annals of Neurology",

issn = "0364-5134",

publisher = "John Wiley and Sons Inc.",

number = "2",

}

TY - JOUR

T1 - Regional variation in brain lactate in leigh syndrome by localized 1H magnetic resonance spectroscopy

AU - Detre, John A.

AU - Wang, Zhiyue

AU - Bogdan, Andrew R.

AU - Gusnard, Debra A.

AU - Bay, Carolyn A.

AU - Bingham, Peter M.

AU - Zimmerman, Robert A.

PY - 1991/2

Y1 - 1991/2

N2 - Localized water‐suppressed 1H magnetic resonance spectroscopy was performed in an 11‐month‐old infant with Leigh syndrome. Spectra obtained from the basal ganglia, occipital cortex, and brainstem showed elevations in lactate, which were most pronounced in regions where abnormalitites were seen with routine T2‐weighted magnetic resonance imaging. This approach has allowed us to examine metabolism in brain tissue directly and noninvasively, and may provide a sensitive means for evaluating metabolic disease and the response to therapy in the brain.

AB - Localized water‐suppressed 1H magnetic resonance spectroscopy was performed in an 11‐month‐old infant with Leigh syndrome. Spectra obtained from the basal ganglia, occipital cortex, and brainstem showed elevations in lactate, which were most pronounced in regions where abnormalitites were seen with routine T2‐weighted magnetic resonance imaging. This approach has allowed us to examine metabolism in brain tissue directly and noninvasively, and may provide a sensitive means for evaluating metabolic disease and the response to therapy in the brain.

UR - http://www.scopus.com/inward/record.url?scp=0025966992&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025966992&partnerID=8YFLogxK

U2 - 10.1002/ana.410290219

DO - 10.1002/ana.410290219

M3 - Article

C2 - 2012390

AN - SCOPUS:0025966992

SN - 0364-5134

VL - 29

SP - 218

EP - 221

JO - Annals of Neurology

JF - Annals of Neurology

IS - 2

ER -

Regional variation in brain lactate in leigh syndrome by localized ¹H magnetic resonance spectroscopy

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this