Regioselective and diastereoselective aminoarylation of 1,3-dienes

Hongli Bao, Liela Bayeh, Uttam K. Tambar

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The 1,4-functionalization of dienes is a synthetically useful strategy for incorporating molecular complexity into a class of simple substrates. We report the aminoarylation of acyclic and cyclic 1,3-dienes via the sequential [4 + 2] cycloaddition with a sulfurdiimide reagent and copper-catalyzed allylic substitution with Grignard reagents. The regioselective and diastereoselective aminoarylation of unsymmetrical dienes is also presented, which highlights the utility of this method for generating products with multiple functional groups and stereocenters. This journal is

Original languageEnglish (US)
Pages (from-to)4863-4867
Number of pages5
JournalChemical Science
Volume5
Issue number12
DOIs
StatePublished - Dec 1 2014

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Cycloaddition
Functional groups
Copper
Substitution reactions
Substrates

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Regioselective and diastereoselective aminoarylation of 1,3-dienes. / Bao, Hongli; Bayeh, Liela; Tambar, Uttam K.

In: Chemical Science, Vol. 5, No. 12, 01.12.2014, p. 4863-4867.

Research output: Contribution to journalArticle

Bao, Hongli ; Bayeh, Liela ; Tambar, Uttam K. / Regioselective and diastereoselective aminoarylation of 1,3-dienes. In: Chemical Science. 2014 ; Vol. 5, No. 12. pp. 4863-4867.
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