Abstract
An efficient method for the synthesis of polysubstituted phenols via the consecutive palladium-catalyzed enyne-diyne [4 + 2] cross-benzannulation reaction and subsequent deprotection step was developed. In all cases, the reactions proceeded in a regiospecific manner affording the corresponding polysubstituted phenols in good overall yields. It was shown that a more useful one-pot methodology could be applied to the synthesis of polysubstituted phenols 4a-e. The synthetically useful p-methoxyphenylacetylene 13 and its monosilylated derivative 12 were smoothly prepared via exhaustive or partial desilylation of bis-silylated aromatic adduct 8c, respectively.
Original language | English (US) |
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Pages (from-to) | 1244-1247 |
Number of pages | 4 |
Journal | Journal of Organic Chemistry |
Volume | 63 |
Issue number | 4 |
DOIs | |
State | Published - Feb 20 1998 |
Externally published | Yes |
ASJC Scopus subject areas
- Organic Chemistry