Regulated Intramembrane Proteolysis

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Regulated intramembrane proteolysis (RIP) is a mechanism for signal transduction that involves the generation of regulatory molecules from membrane proteins through proteolytic cleavage. Such cleavage liberates cytoplasmic or lumenal/extracellular fragments from transmembrane precursor proteins, allowing the cleaved fragments to function at a new location. RIP influences processes as diverse as cellular differentiation, lipid metabolism, immune defense, and the response to unfolded proteins. Proteins that are known to undergo RIP span the membrane bilayer at least once. The intramembrane cleavage of RIP is mediated by four different families of membrane-bound proteases: Site-2 protease (S2P), γ-Secretase, Signal peptide peptidase (SPP), and Rhomboid. In addition to its occurrence in animal cells, RIP has been observed in lower organism including bacteria, and, remarkably, the bacterial proteases are related evolutionarily to the ones used in animal cells.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Biological Chemistry
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages50-55
Number of pages6
ISBN (Electronic)9780123786319
ISBN (Print)9780123786302
DOIs
StatePublished - Feb 15 2013

Fingerprint

Proteolysis
Peptide Hydrolases
Animals
Cells
Membranes
Unfolded Protein Response
Amyloid Precursor Protein Secretases
Signal transduction
Protein Precursors
Lipid Metabolism
Signal Transduction
Bacteria
Membrane Proteins
Proteins
Molecules

Keywords

  • Alzheimer's disease
  • Cholesterol metabolism
  • Presenilin
  • Protease
  • Regulated intramembrane proteolysis (RIP)
  • Rhomboid
  • Signal-peptide peptidase (SPP)
  • Site-2 protease (S2P)
  • γ-Secretase

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Ye, J. (2013). Regulated Intramembrane Proteolysis. In Encyclopedia of Biological Chemistry: Second Edition (pp. 50-55). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-378630-2.00065-7

Regulated Intramembrane Proteolysis. / Ye, J.

Encyclopedia of Biological Chemistry: Second Edition. Elsevier Inc., 2013. p. 50-55.

Research output: Chapter in Book/Report/Conference proceedingChapter

Ye, J 2013, Regulated Intramembrane Proteolysis. in Encyclopedia of Biological Chemistry: Second Edition. Elsevier Inc., pp. 50-55. https://doi.org/10.1016/B978-0-12-378630-2.00065-7
Ye J. Regulated Intramembrane Proteolysis. In Encyclopedia of Biological Chemistry: Second Edition. Elsevier Inc. 2013. p. 50-55 https://doi.org/10.1016/B978-0-12-378630-2.00065-7
Ye, J. / Regulated Intramembrane Proteolysis. Encyclopedia of Biological Chemistry: Second Edition. Elsevier Inc., 2013. pp. 50-55
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