Regulating mammalian transcription with RNA

David R. Corey

doi:10.1016/j.tibs.2005.09.007

Regulating mammalian transcription with RNA

David R. Corey

Research output: Contribution to journal › Short survey › peer-review

24 Scopus citations

Abstract

Recent reports have demonstrated that small duplex RNAs mediate recognition of chromosomal DNA and inhibit transcription within mammalian cells. Key unresolved issues include whether RNAs directly bind to DNA, the identification of the mechanism(s) that convert chromosome recognition into gene silencing and whether naturally occurring antigene RNAs (agRNAs) exist.

Original language	English (US)
Pages (from-to)	655-658
Number of pages	4
Journal	Trends in biochemical sciences
Volume	30
Issue number	12
DOIs	https://doi.org/10.1016/j.tibs.2005.09.007
State	Published - Dec 2005

ASJC Scopus subject areas

Biochemistry
Molecular Biology

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10.1016/j.tibs.2005.09.007

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title = "Regulating mammalian transcription with RNA",

abstract = "Recent reports have demonstrated that small duplex RNAs mediate recognition of chromosomal DNA and inhibit transcription within mammalian cells. Key unresolved issues include whether RNAs directly bind to DNA, the identification of the mechanism(s) that convert chromosome recognition into gene silencing and whether naturally occurring antigene RNAs (agRNAs) exist.",

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journal = "Trends in biochemical sciences",

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AB - Recent reports have demonstrated that small duplex RNAs mediate recognition of chromosomal DNA and inhibit transcription within mammalian cells. Key unresolved issues include whether RNAs directly bind to DNA, the identification of the mechanism(s) that convert chromosome recognition into gene silencing and whether naturally occurring antigene RNAs (agRNAs) exist.

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JO - Trends in biochemical sciences

JF - Trends in biochemical sciences

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Regulating mammalian transcription with RNA

Abstract

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