Regulating mammalian transcription with RNA

Research output: Contribution to journalShort surveypeer-review

23 Scopus citations


Recent reports have demonstrated that small duplex RNAs mediate recognition of chromosomal DNA and inhibit transcription within mammalian cells. Key unresolved issues include whether RNAs directly bind to DNA, the identification of the mechanism(s) that convert chromosome recognition into gene silencing and whether naturally occurring antigene RNAs (agRNAs) exist.

Original languageEnglish (US)
Pages (from-to)655-658
Number of pages4
JournalTrends in Biochemical Sciences
Issue number12
StatePublished - Dec 1 2005

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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