Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing

Qi Chen, Lijun Sun, Zhijian J. Chen

Research output: Contribution to journalReview article

415 Scopus citations

Abstract

The recognition of microbial nucleic acids is a major mechanism by which the immune system detects pathogens. Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a cytosolic DNA sensor that activates innate immune responses through production of the second messenger cGAMP, which activates the adaptor STING. The cGAS-STING pathway not only mediates protective immune defense against infection by a large variety of DNA-containing pathogens but also detects tumor-derived DNA and generates intrinsic antitumor immunity. However, aberrant activation of the cGAS pathway by self DNA can also lead to autoimmune and inflammatory disease. Thus, the cGAS pathway must be properly regulated. Here we review the recent advances in understanding of the cGAS-STING pathway, focusing on the regulatory mechanisms and roles of this pathway in heath and disease.

Original languageEnglish (US)
Pages (from-to)1142-1149
Number of pages8
JournalNature Immunology
Volume17
Issue number10
DOIs
StatePublished - Sep 20 2016

ASJC Scopus subject areas

  • Immunology

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