Regulation dynamics of WGD genes during yeast metabolic oscillation

Hong Chen, Lin Xu, Zhenglong Gu

Research output: Contribution to journalArticlepeer-review

Abstract

Saccharomyces cerevisiae and its close relatives are characterized by their propensity to ferment even in the presence of oxygen. It was hypothesized that whole-genome duplication (WGD) led to the development of this efficient fermentative lifestyle (WGD-fermentation hypothesis, Piskur 2001. In this study, we found that a significantly higher proportion of WGD genes than non-WGD genes are dynamically regulated during metabolic oscillation in response to oxygen change. The same data set also shows that the WGD genes, as compared with the smaller scale duplicate genes, are enriched with pairs where both copies have cyclic expression during the metabolic oscillation (either with the same or different phases). These results provide new evidences for the WGD-fermentation hypothesis and new insights into the relationship between the genome duplication and the evolution of new lifestyles in eukaryotic organisms.

Original languageEnglish (US)
Pages (from-to)2513-2516
Number of pages4
JournalMolecular biology and evolution
Volume25
Issue number12
DOIs
StatePublished - Dec 2008

Keywords

  • Metabolic cycling genes
  • WGD
  • WGD-fermentation hypothesis
  • Yeast

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics

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