TY - JOUR
T1 - Regulation of APC-Cdc20 by the spindle checkpoint
AU - Yu, Hongtao
N1 - Funding Information:
I thank Bonnie Howell, Andy Hoyt, Marc Kirschner, Ted Salmon, Tim Yen and Hui Zou for reading the manuscript critically and for providing insightful comments. I also thank Xuelian Luo, Jose Rizo-Rey and members of my laboratory for helpful discussions. The work in my laboratory is supported by the National Institutes of Health, the Packard Foundation, the Burroughs Wellcome Fund and the Welch Foundation.
PY - 2002/12/1
Y1 - 2002/12/1
N2 - The spindle checkpoint ensures the fidelity of chromosome segregation in mitosis and meiosis. In response to defects in the mitotic apparatus, it blocks the activity of the anaphase-promoting complex, a large ubiquitin ligase required for chromosome segregation. Recent studies indicate that the spindle checkpoint monitors both the attachment of chromosomes to the mitotic spindle and the tension across the sister chromatid generated by microtubules. Upon checkpoint activation, checkpoint protein complexes containing BubR1(Mad3), Bub3, Mad2 and Cdc20 directly bind to the anaphase-promoting complex and inhibit its ligase activity. Therefore, the checkpoint proteins form a complex intracellular signalling network to inhibit the anaphase-promoting complex.
AB - The spindle checkpoint ensures the fidelity of chromosome segregation in mitosis and meiosis. In response to defects in the mitotic apparatus, it blocks the activity of the anaphase-promoting complex, a large ubiquitin ligase required for chromosome segregation. Recent studies indicate that the spindle checkpoint monitors both the attachment of chromosomes to the mitotic spindle and the tension across the sister chromatid generated by microtubules. Upon checkpoint activation, checkpoint protein complexes containing BubR1(Mad3), Bub3, Mad2 and Cdc20 directly bind to the anaphase-promoting complex and inhibit its ligase activity. Therefore, the checkpoint proteins form a complex intracellular signalling network to inhibit the anaphase-promoting complex.
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U2 - 10.1016/S0955-0674(02)00382-4
DO - 10.1016/S0955-0674(02)00382-4
M3 - Review article
C2 - 12473343
AN - SCOPUS:0036902234
SN - 0955-0674
VL - 14
SP - 706
EP - 714
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 6
ER -