Regulation of APC-Cdc20 by the spindle checkpoint

Hongtao Yu

Research output: Contribution to journalReview article

279 Scopus citations

Abstract

The spindle checkpoint ensures the fidelity of chromosome segregation in mitosis and meiosis. In response to defects in the mitotic apparatus, it blocks the activity of the anaphase-promoting complex, a large ubiquitin ligase required for chromosome segregation. Recent studies indicate that the spindle checkpoint monitors both the attachment of chromosomes to the mitotic spindle and the tension across the sister chromatid generated by microtubules. Upon checkpoint activation, checkpoint protein complexes containing BubR1(Mad3), Bub3, Mad2 and Cdc20 directly bind to the anaphase-promoting complex and inhibit its ligase activity. Therefore, the checkpoint proteins form a complex intracellular signalling network to inhibit the anaphase-promoting complex.

Original languageEnglish (US)
Pages (from-to)706-714
Number of pages9
JournalCurrent Opinion in Cell Biology
Volume14
Issue number6
DOIs
StatePublished - Dec 1 2002

ASJC Scopus subject areas

  • Cell Biology

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