Regulation of atrial natriuretic peptide secretion by a novel Ras-like protein

Igor I. Rybkin, Mi Sung Kim, Svetlana Bezprozvannaya, Xiaoxia Qi, James A Richardson, Craig F. Plato, Joseph A Hill, Rhonda S Bassel-Duby, Eric N Olson

Research output: Contribution to journalArticle

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Abstract

A trial cardiomyocytes, neurons, and endocrine tissues secrete neurotransmitters and peptide hormones via large dense-core vesicles (LDCVs). We describe a new member of the Ras family of G-proteins, named RRP17, which is expressed specifically in cardiomyocytes, neurons, and the pancreas. RRP17 interacts with Ca2+-activated protein for secretion-1 (CAPS1), one of only a few proteins known to be associated exclusively with LDCV exocytosis. Ectopic expression of RRP17 in cardiomyocytes enhances secretion of atrial natriuretic peptide (ANP), a regulator of blood pressure and natriuresis. Conversely, genetic deletion of RRP17 in mice results in dysmorphic LDCVs, impaired ANP secretion, and hypertension. These findings identify RRP17 as a component of the cellular machinery involved in regulated secretion within the heart and potential mediator of the endocrine influence of the heart on other tissues.

Original languageEnglish (US)
Pages (from-to)527-537
Number of pages11
JournalJournal of Cell Biology
Volume179
Issue number3
DOIs
StatePublished - Nov 5 2007

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ASJC Scopus subject areas

  • Cell Biology

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