Regulation of autophagy by insulin/IGF-1 signaling pathways

Rodrigo Troncoso; César Vásquez-Trincado; Andrea Del Campo; Damián Gatica; Pablo E. Morales; Felipe Paredes; Natalia Torrealba; Camila Lopez-Crisosto; Zully Pedrozo; Lorena Garda; Guillermo Díaz-Araya; Pavan K. Battiprolu; Andriy Nemchenko; Anwarul Ferdous; Thomas G. Gillette; Joseph A Hill; Sergio Lavandero

Regulation of autophagy by insulin/IGF-1 signaling pathways

Rodrigo Troncoso, César Vásquez-Trincado, Andrea Del Campo, Damián Gatica, Pablo E. Morales, Felipe Paredes, Natalia Torrealba, Camila Lopez-Crisosto, Zully Pedrozo, Lorena Garda, Guillermo Díaz-Araya, Pavan K. Battiprolu, Andriy Nemchenko, Anwarul Ferdous, Thomas G. Gillette, Joseph A Hill, Sergio Lavandero

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Insulin and insulin-like growth factor-1 (IGF-1) share a high degree of structural homology and biological actions. Both peptides mediate several cellular processes involved mostly in metabolism and growth. Insulin is mainly implicated in the maintenance of energy balance whereas IGF-1 is essential for normal growth, development and differentiation. Autophagy is one of the key catabolic process regulated by insulin/IGF-1. In recent years, autophagic activity has been linked with multiple pathological conditions in patients. However, the underlying signaling mechanisms mediating the regulation of autophagy by insulin/IGF-1 and its consequences in the settings of cancer, atrophy, aging and diabetes are less understood. This review is focused on the interface between insulin/IGF-1 pathways and autophagy with emphasis on these pathologies.

Original language	English (US)
Title of host publication	Autophagy
Subtitle of host publication	Principles, Regulation and Roles in Disease
Publisher	Nova Science Publishers, Inc.
Pages	181-194
Number of pages	14
ISBN (Print)	9781619422667
State	Published - 2012

Keywords

Autophagy
Cancer
Diabetes
Growth factors
Longevity
Metabolism

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Cite this

Troncoso, R., Vásquez-Trincado, C., Campo, A. D., Gatica, D., Morales, P. E., Paredes, F., Torrealba, N., Lopez-Crisosto, C., Pedrozo, Z., Garda, L., Díaz-Araya, G., Battiprolu, P. K., Nemchenko, A., Ferdous, A., Gillette, T. G., Hill, J. A., & Lavandero, S. (2012). Regulation of autophagy by insulin/IGF-1 signaling pathways. In Autophagy: Principles, Regulation and Roles in Disease (pp. 181-194). Nova Science Publishers, Inc..

Troncoso, R, Vásquez-Trincado, C, Campo, AD, Gatica, D, Morales, PE, Paredes, F, Torrealba, N, Lopez-Crisosto, C, Pedrozo, Z, Garda, L, Díaz-Araya, G, Battiprolu, PK, Nemchenko, A, Ferdous, A, Gillette, TG, Hill, JA & Lavandero, S 2012, Regulation of autophagy by insulin/IGF-1 signaling pathways. in Autophagy: Principles, Regulation and Roles in Disease. Nova Science Publishers, Inc., pp. 181-194.

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AU - Morales, Pablo E.

AU - Paredes, Felipe

AU - Torrealba, Natalia

AU - Lopez-Crisosto, Camila

AU - Pedrozo, Zully

AU - Garda, Lorena

AU - Díaz-Araya, Guillermo

AU - Battiprolu, Pavan K.

AU - Nemchenko, Andriy

AU - Ferdous, Anwarul

AU - Gillette, Thomas G.

AU - Hill, Joseph A

AU - Lavandero, Sergio

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AB - Insulin and insulin-like growth factor-1 (IGF-1) share a high degree of structural homology and biological actions. Both peptides mediate several cellular processes involved mostly in metabolism and growth. Insulin is mainly implicated in the maintenance of energy balance whereas IGF-1 is essential for normal growth, development and differentiation. Autophagy is one of the key catabolic process regulated by insulin/IGF-1. In recent years, autophagic activity has been linked with multiple pathological conditions in patients. However, the underlying signaling mechanisms mediating the regulation of autophagy by insulin/IGF-1 and its consequences in the settings of cancer, atrophy, aging and diabetes are less understood. This review is focused on the interface between insulin/IGF-1 pathways and autophagy with emphasis on these pathologies.

KW - Autophagy

KW - Cancer

KW - Diabetes

KW - Growth factors

KW - Longevity

KW - Metabolism

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BT - Autophagy

PB - Nova Science Publishers, Inc.

ER -

Regulation of autophagy by insulin/IGF-1 signaling pathways

Abstract

Keywords

ASJC Scopus subject areas

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