Regulation of autophagy by insulin/IGF-1 signaling pathways

Rodrigo Troncoso, César Vásquez-Trincado, Andrea Del Campo, Damián Gatica, Pablo E. Morales, Felipe Paredes, Natalia Torrealba, Camila Lopez-Crisosto, Zully Pedrozo, Lorena Garda, Guillermo Díaz-Araya, Pavan K. Battiprolu, Andriy Nemchenko, Anwarul Ferdous, Thomas G. Gillette, Joseph A Hill, Sergio Lavandero

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Insulin and insulin-like growth factor-1 (IGF-1) share a high degree of structural homology and biological actions. Both peptides mediate several cellular processes involved mostly in metabolism and growth. Insulin is mainly implicated in the maintenance of energy balance whereas IGF-1 is essential for normal growth, development and differentiation. Autophagy is one of the key catabolic process regulated by insulin/IGF-1. In recent years, autophagic activity has been linked with multiple pathological conditions in patients. However, the underlying signaling mechanisms mediating the regulation of autophagy by insulin/IGF-1 and its consequences in the settings of cancer, atrophy, aging and diabetes are less understood. This review is focused on the interface between insulin/IGF-1 pathways and autophagy with emphasis on these pathologies.

Original languageEnglish (US)
Title of host publicationAutophagy: Principles, Regulation and Roles in Disease
PublisherNova Science Publishers, Inc.
Pages181-194
Number of pages14
ISBN (Print)9781619422667
StatePublished - 2012

Fingerprint

Autophagy
Somatomedins
Insulin
Pathology
Medical problems
Energy balance
Growth and Development
Metabolism
Atrophy
Aging of materials
Maintenance
Peptides
Growth
Neoplasms

Keywords

  • Autophagy
  • Cancer
  • Diabetes
  • Growth factors
  • Longevity
  • Metabolism

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Troncoso, R., Vásquez-Trincado, C., Campo, A. D., Gatica, D., Morales, P. E., Paredes, F., ... Lavandero, S. (2012). Regulation of autophagy by insulin/IGF-1 signaling pathways. In Autophagy: Principles, Regulation and Roles in Disease (pp. 181-194). Nova Science Publishers, Inc..

Regulation of autophagy by insulin/IGF-1 signaling pathways. / Troncoso, Rodrigo; Vásquez-Trincado, César; Campo, Andrea Del; Gatica, Damián; Morales, Pablo E.; Paredes, Felipe; Torrealba, Natalia; Lopez-Crisosto, Camila; Pedrozo, Zully; Garda, Lorena; Díaz-Araya, Guillermo; Battiprolu, Pavan K.; Nemchenko, Andriy; Ferdous, Anwarul; Gillette, Thomas G.; Hill, Joseph A; Lavandero, Sergio.

Autophagy: Principles, Regulation and Roles in Disease. Nova Science Publishers, Inc., 2012. p. 181-194.

Research output: Chapter in Book/Report/Conference proceedingChapter

Troncoso, R, Vásquez-Trincado, C, Campo, AD, Gatica, D, Morales, PE, Paredes, F, Torrealba, N, Lopez-Crisosto, C, Pedrozo, Z, Garda, L, Díaz-Araya, G, Battiprolu, PK, Nemchenko, A, Ferdous, A, Gillette, TG, Hill, JA & Lavandero, S 2012, Regulation of autophagy by insulin/IGF-1 signaling pathways. in Autophagy: Principles, Regulation and Roles in Disease. Nova Science Publishers, Inc., pp. 181-194.
Troncoso R, Vásquez-Trincado C, Campo AD, Gatica D, Morales PE, Paredes F et al. Regulation of autophagy by insulin/IGF-1 signaling pathways. In Autophagy: Principles, Regulation and Roles in Disease. Nova Science Publishers, Inc. 2012. p. 181-194
Troncoso, Rodrigo ; Vásquez-Trincado, César ; Campo, Andrea Del ; Gatica, Damián ; Morales, Pablo E. ; Paredes, Felipe ; Torrealba, Natalia ; Lopez-Crisosto, Camila ; Pedrozo, Zully ; Garda, Lorena ; Díaz-Araya, Guillermo ; Battiprolu, Pavan K. ; Nemchenko, Andriy ; Ferdous, Anwarul ; Gillette, Thomas G. ; Hill, Joseph A ; Lavandero, Sergio. / Regulation of autophagy by insulin/IGF-1 signaling pathways. Autophagy: Principles, Regulation and Roles in Disease. Nova Science Publishers, Inc., 2012. pp. 181-194
@inbook{f97c79bc4ddf4fd49659fbdd9972dc86,
title = "Regulation of autophagy by insulin/IGF-1 signaling pathways",
abstract = "Insulin and insulin-like growth factor-1 (IGF-1) share a high degree of structural homology and biological actions. Both peptides mediate several cellular processes involved mostly in metabolism and growth. Insulin is mainly implicated in the maintenance of energy balance whereas IGF-1 is essential for normal growth, development and differentiation. Autophagy is one of the key catabolic process regulated by insulin/IGF-1. In recent years, autophagic activity has been linked with multiple pathological conditions in patients. However, the underlying signaling mechanisms mediating the regulation of autophagy by insulin/IGF-1 and its consequences in the settings of cancer, atrophy, aging and diabetes are less understood. This review is focused on the interface between insulin/IGF-1 pathways and autophagy with emphasis on these pathologies.",
keywords = "Autophagy, Cancer, Diabetes, Growth factors, Longevity, Metabolism",
author = "Rodrigo Troncoso and C{\'e}sar V{\'a}squez-Trincado and Campo, {Andrea Del} and Dami{\'a}n Gatica and Morales, {Pablo E.} and Felipe Paredes and Natalia Torrealba and Camila Lopez-Crisosto and Zully Pedrozo and Lorena Garda and Guillermo D{\'i}az-Araya and Battiprolu, {Pavan K.} and Andriy Nemchenko and Anwarul Ferdous and Gillette, {Thomas G.} and Hill, {Joseph A} and Sergio Lavandero",
year = "2012",
language = "English (US)",
isbn = "9781619422667",
pages = "181--194",
booktitle = "Autophagy: Principles, Regulation and Roles in Disease",
publisher = "Nova Science Publishers, Inc.",

}

TY - CHAP

T1 - Regulation of autophagy by insulin/IGF-1 signaling pathways

AU - Troncoso, Rodrigo

AU - Vásquez-Trincado, César

AU - Campo, Andrea Del

AU - Gatica, Damián

AU - Morales, Pablo E.

AU - Paredes, Felipe

AU - Torrealba, Natalia

AU - Lopez-Crisosto, Camila

AU - Pedrozo, Zully

AU - Garda, Lorena

AU - Díaz-Araya, Guillermo

AU - Battiprolu, Pavan K.

AU - Nemchenko, Andriy

AU - Ferdous, Anwarul

AU - Gillette, Thomas G.

AU - Hill, Joseph A

AU - Lavandero, Sergio

PY - 2012

Y1 - 2012

N2 - Insulin and insulin-like growth factor-1 (IGF-1) share a high degree of structural homology and biological actions. Both peptides mediate several cellular processes involved mostly in metabolism and growth. Insulin is mainly implicated in the maintenance of energy balance whereas IGF-1 is essential for normal growth, development and differentiation. Autophagy is one of the key catabolic process regulated by insulin/IGF-1. In recent years, autophagic activity has been linked with multiple pathological conditions in patients. However, the underlying signaling mechanisms mediating the regulation of autophagy by insulin/IGF-1 and its consequences in the settings of cancer, atrophy, aging and diabetes are less understood. This review is focused on the interface between insulin/IGF-1 pathways and autophagy with emphasis on these pathologies.

AB - Insulin and insulin-like growth factor-1 (IGF-1) share a high degree of structural homology and biological actions. Both peptides mediate several cellular processes involved mostly in metabolism and growth. Insulin is mainly implicated in the maintenance of energy balance whereas IGF-1 is essential for normal growth, development and differentiation. Autophagy is one of the key catabolic process regulated by insulin/IGF-1. In recent years, autophagic activity has been linked with multiple pathological conditions in patients. However, the underlying signaling mechanisms mediating the regulation of autophagy by insulin/IGF-1 and its consequences in the settings of cancer, atrophy, aging and diabetes are less understood. This review is focused on the interface between insulin/IGF-1 pathways and autophagy with emphasis on these pathologies.

KW - Autophagy

KW - Cancer

KW - Diabetes

KW - Growth factors

KW - Longevity

KW - Metabolism

UR - http://www.scopus.com/inward/record.url?scp=84891998759&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84891998759&partnerID=8YFLogxK

M3 - Chapter

AN - SCOPUS:84891998759

SN - 9781619422667

SP - 181

EP - 194

BT - Autophagy: Principles, Regulation and Roles in Disease

PB - Nova Science Publishers, Inc.

ER -