Regulation of biologically active dimeric inhibin A and B from infancy to adulthood in the male

William Byrd, Michael J. Bennett, Bruce R. Carr, Y. Dong, Frank Wians, William Rainey

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Inhibins are glycoprotein members of the transforming growth factor-β family that have been implicated in the control of spermatogenesis by exerting a negative feedback on FSH secretion. In addition, locally produced inhibins may play a role in paracrine regulation of testicular function. Immunoassays were used to measure the two biologically active dimeric forms of inhibin (inhibin A and B) in serum, seminal plasma, and urine. To better define their actions, inhibins were measured in the male during infancy, sexual maturation, and senescence. Inhibin B but not A was measurable in the serum of male newborns, infants, children, and adults. In adult males, measurable levels of inhibin B were detected in the seminal plasma but not the urine. The circulating levels of inhibin B increased shortly after birth and peaked at 4-12 months of age (210 ± 31 pg/mL). The concentration measured in the serum then decreased to a low of 81 ± 12 pg/mL of inhibin B from 3-9 yr of age followed by a gradual increase beginning with the onset of puberty and reaching another peak of 167 ± 20 pg/mL in males who were 20-30 yr of age. Inhibin B levels then gradually declined with increasing age up through 90 yr of age. Serum levels of gonadotropins and total testosterone production were also measured in these same males. There was a brief increase in the gonadotropins (FSH and LH) during the few months of postnatal development, followed by a decrease to basal levels until the onset of puberty at 10-14 yr of age. Testosterone was also increased in the serum of infants from day 1 through 12 months of age, which decreased in young children but increased again following the elevation of gonadotropins during puberty. In adults aged 20-90 yr, serum levels of inhibin B were inversely proportional to levels of FSH but not LH or testosterone. In males in which a semen analysis was performed, those males with normal semen analysis had a significantly higher inhibin B levels, sperm production, and lower FSH levels than males with either oligospermia or nonobstructive azoospermia. The levels of Inhibin B found in circulation were a good marker for testicular function and could be useful in the diagnosis of patients with semen abnormalities or a complete absence of spermatogenesis. Because this glycoprotein is secreted in high amounts in the prepubertal testis up to 3 yr of age, inhibin B could potentially be used as a marker in the diagnosis of cryptorchidism and precocious puberty.

Original languageEnglish (US)
Pages (from-to)2849-2854
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume83
Issue number8
DOIs
StatePublished - 1998

Fingerprint

Inhibins
Puberty
Semen
Serum
Gonadotropins
Testosterone
Semen Analysis
Spermatogenesis
Glycoproteins
inhibin A
inhibin B
Urine
Plasmas
Oligospermia
Precocious Puberty
Sexual Maturation
Cryptorchidism
Transforming Growth Factors
Immunoassay
Spermatozoa

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Regulation of biologically active dimeric inhibin A and B from infancy to adulthood in the male. / Byrd, William; Bennett, Michael J.; Carr, Bruce R.; Dong, Y.; Wians, Frank; Rainey, William.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 83, No. 8, 1998, p. 2849-2854.

Research output: Contribution to journalArticle

Byrd, William ; Bennett, Michael J. ; Carr, Bruce R. ; Dong, Y. ; Wians, Frank ; Rainey, William. / Regulation of biologically active dimeric inhibin A and B from infancy to adulthood in the male. In: Journal of Clinical Endocrinology and Metabolism. 1998 ; Vol. 83, No. 8. pp. 2849-2854.
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