Regulation of CDC14

pathways and checkpoints of mitotic exit.

Joshua Bembenek, Hongtao Yu

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Progression of the mitotic cell cycle is driven by fluctuations of the cyclin-dependent kinase (Cdk) activities. Entry into mitosis is promoted by the elevated activity of Cdk1 associated with B-type cyclins. Conversely, exit from mitosis requires the inactivation of Cdk1 and the dephosphorylation of at least a subset of Cdk1 substrates. The Cdc14 family of phosphatases antagonizes the action of Cdk1, and is thus a major player in controlling the mitotic exit. We review recent discoveries in several model systems that have shed light on the function of Cdc14 and propose a general framework within which Cdc14 plays conserved roles in regulating the exit from mitosis and cytokinesis.

Original languageEnglish (US)
JournalFrontiers in bioscience : a journal and virtual library
Volume8
StatePublished - 2003

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M Phase Cell Cycle Checkpoints
Cyclin B
Cyclin-Dependent Kinases
Phosphoric Monoester Hydrolases
Mitosis
Cells
Substrates
Cytokinesis
Cell Cycle

Cite this

Regulation of CDC14 : pathways and checkpoints of mitotic exit. / Bembenek, Joshua; Yu, Hongtao.

In: Frontiers in bioscience : a journal and virtual library, Vol. 8, 2003.

Research output: Contribution to journalArticle

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