Regulation of cell lineage specification by the retinoblastoma tumor suppressor

S. X. Skapek, Y. R. Pan, E. Y H P Lee

Research output: Contribution to journalReview article

30 Scopus citations

Abstract

Early studies of the retinoblastoma gene (RB) have uncovered its critical role as a regulator of the G1/S cell cycle phase progression. Surprisingly, genetic approaches in mammals and nematodes have also shown RB controls cell lineage specification and aspects of differentiation. The RB gene product accomplishes this by diverse mechanisms such as by interacting with tissue-specific transcription factors, enhancing RNA interference, and modifying chromatin structure. We review recent studies uncovering novel mechanisms by which RB works in several cell lineages and we provide perspectives on how these new findings might relate to RB tumor suppression.

Original languageEnglish (US)
Pages (from-to)5268-5276
Number of pages9
JournalOncogene
Volume25
Issue number38
DOIs
StatePublished - Aug 28 2006

Keywords

  • Cellular differentiation
  • Retinoblastoma susceptibility gene
  • Tumor suppressor gene

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Fingerprint Dive into the research topics of 'Regulation of cell lineage specification by the retinoblastoma tumor suppressor'. Together they form a unique fingerprint.

  • Cite this