Regulation of central blood volume and cardiac filling in endurance athletes: The Frank-Starling mechanism as a determinant of orthostatic tolerance

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73 Citations (Scopus)

Abstract

Orthostatic intolerance may result from either an abnormally large postural decrease in central blood volume, cardiac filling pressures, and stroke volume, or inadequate neurohumoral responses to orthostasis. Endurance athletes have been reported as having a high incidence of orthostatic intolerance, which has been attributed primarily to abnormalities in baroreflex regulation of heart rate and peripheral resistance. In this review, we present evidence that athletes also have structural changes in the cardiovascular system that although beneficial during exercise, lead to an excessively large decrease in stroke volume during orthostasis and contribute to orthostatic intolerance. A unifying hypothesis based on cardiac mechanics that may explain the divergence of findings in conditions such as bed rest or spaceflight, and short- and long-term endurance training is presented.

Original languageEnglish (US)
Pages (from-to)727-732
Number of pages6
JournalMedicine and Science in Sports and Exercise
Volume25
Issue number6
StatePublished - 1993

Fingerprint

Orthostatic Intolerance
Starlings
Blood Volume
Athletes
Dizziness
Stroke Volume
Space Flight
Bed Rest
Baroreflex
Cardiovascular System
Mechanics
Vascular Resistance
Heart Rate
Exercise
Pressure
Incidence

Keywords

  • CENTRAL BLOOD VOLUME
  • DIASTOLIC FUNCTION
  • ENDURANCE ATHLETES
  • FRANK-STARLING MECHANISM
  • ORTHOSTATIC INTOLERANCE

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Public Health, Environmental and Occupational Health
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

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