Regulation of Cholesterol Metabolism

J. M. Dietschy, J. D. Wilson

Research output: Contribution to journalReview article

112 Scopus citations

Abstract

Absorption of Cholesterol Mechanisms of cholesterol absorption. The second source of cholesterol entering the miscible pools is dietary or exogenous cholesterol. The essential features of the process whereby dietary cholesterol is absorbed and eventually reaches the circulation is shown diagrammatically in Figure 9.6 Cholesterol within the intestinal lumen consists of a mixture of free and esterified cholesterol of both exogenous (dietary) and endogenous origin, the latter being derived chiefly from sterols reaching the intestinal lumen in bile and other intestinal secretions and from desquamation of mucosal cells. In the presence of pancreatic cholesterol esterase and bile acid, cholesterol esters are hydrolized.

Original languageEnglish (US)
Pages (from-to)1179-1183
Number of pages5
JournalNew England Journal of Medicine
Volume282
Issue number21
DOIs
StatePublished - May 21 1970

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Regulation of Cholesterol Metabolism'. Together they form a unique fingerprint.

  • Cite this