Regulation of Cholesterol Metabolism

J. M. Dietschy, J. D. Wilson

Research output: Contribution to journalReview articlepeer-review

201 Scopus citations

Abstract

THE central features of the mechanisms by which cholesterol metabolism is regulated in intact animals were clearly elucidated in 1933 by Schoenheimer and Breusch1 — namely, that the synthesis, absorption and destruction of cholesterol in the mammal is controlled by complex interlocking feedback mechanism (or mechanisms), of which bile acids and cholesterol themselves are the principal mediators. In view of the fact that this superstructure for cholesterol metabolism was developed before the introduction of isotopic technics into biologic research, it is surprising that the intimate details of the regulatory mechanisms themselves and the means by which the regulatory mechanisms interdigitate.

Original languageEnglish (US)
Pages (from-to)1128-1138
Number of pages11
JournalNew England Journal of Medicine
Volume282
Issue number20
DOIs
StatePublished - May 14 1970

ASJC Scopus subject areas

  • Medicine(all)

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