Regulation of chromatin structure and chromatin-dependent transcription by poly(ADP-Ribose) polymerase-1: Possible targets for drug-based therapies

David A. Wacker, Kristine M. Frizzell, Tong Zhang, W. Lee Kraus

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Poly(ADP-Ribose) Polymerase-1 (PARP-1) is the prototypical and most abundantly expressed member of a family of PARPs that catalyze the polymerization of ADP-ribose (ADPR) units from donor NAD+ molecules on target proteins. PARP-1 plays roles in a variety of genomic processes, including the regulation of chromatin structure and transcription in response to specific cellular signals. PARP-1 also plays important roles in many stress-induced disease states. In this chapter, we review the molecular and cellular aspects of PARP-1’s chromatin-modulating activities, as well as the impact that these chromatin-modulating activities have on the regulation of gene expression. In addition, we highlight the potential therapeutic use of drugs that target PARP-1’s enzymatic activity for the treatment of human diseases.

Original languageEnglish (US)
Pages (from-to)45-69
Number of pages25
JournalSub-Cellular Biochemistry
Volume41
StatePublished - Jan 1 2007

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology
  • Cancer Research

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