Regulation of Dendritic Development by Neuron-Specific Chromatin Remodeling Complexes

Jiang I. Wu, Julie Lessard, Ivan A. Olave, Zilong Qiu, Anirvan Ghosh, Isabella A. Graef, Gerald R. Crabtree

Research output: Contribution to journalArticle

243 Citations (Scopus)

Abstract

The diversity of dendritic patterns is one of the fundamental characteristics of neurons and is in part regulated by transcriptional programs initiated by electrical activity. We show that dendritic outgrowth requires a family of combinatorially assembled, neuron-specific chromatin remodeling complexes (nBAF complexes) distinguished by the actin-related protein BAF53b and based on the Brg/Brm ATPases. nBAF complexes bind tightly to the Ca2+-responsive dendritic regulator CREST and directly regulate genes essential for dendritic outgrowth. BAF53b is not required for nBAF complex assembly or the interaction with CREST, yet is required for their recruitment to the promoters of specific target genes. The highly homologous BAF53a protein, which is a component of neural progenitor and nonneural BAF complexes, cannot replace BAF53b's role in dendritic development. Remarkably, we find that this functional specificity is conferred by the actin fold subdomain 2 of BAF53b. These studies suggest that the genes encoding the individual subunits of BAF complexes function like letters in a ten-letter word to produce biologically specific meanings (in this case dendritic outgrowth) by combinatorial assembly of their products.

Original languageEnglish (US)
Pages (from-to)94-108
Number of pages15
JournalNeuron
Volume56
Issue number1
DOIs
StatePublished - Oct 4 2007

Fingerprint

Chromatin Assembly and Disassembly
Actins
Neurons
Essential Genes
Genes
Adenosine Triphosphatases
Proteins

Keywords

  • DEVBIO
  • DNA
  • MOLNEURO

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Wu, J. I., Lessard, J., Olave, I. A., Qiu, Z., Ghosh, A., Graef, I. A., & Crabtree, G. R. (2007). Regulation of Dendritic Development by Neuron-Specific Chromatin Remodeling Complexes. Neuron, 56(1), 94-108. https://doi.org/10.1016/j.neuron.2007.08.021

Regulation of Dendritic Development by Neuron-Specific Chromatin Remodeling Complexes. / Wu, Jiang I.; Lessard, Julie; Olave, Ivan A.; Qiu, Zilong; Ghosh, Anirvan; Graef, Isabella A.; Crabtree, Gerald R.

In: Neuron, Vol. 56, No. 1, 04.10.2007, p. 94-108.

Research output: Contribution to journalArticle

Wu, JI, Lessard, J, Olave, IA, Qiu, Z, Ghosh, A, Graef, IA & Crabtree, GR 2007, 'Regulation of Dendritic Development by Neuron-Specific Chromatin Remodeling Complexes', Neuron, vol. 56, no. 1, pp. 94-108. https://doi.org/10.1016/j.neuron.2007.08.021
Wu, Jiang I. ; Lessard, Julie ; Olave, Ivan A. ; Qiu, Zilong ; Ghosh, Anirvan ; Graef, Isabella A. ; Crabtree, Gerald R. / Regulation of Dendritic Development by Neuron-Specific Chromatin Remodeling Complexes. In: Neuron. 2007 ; Vol. 56, No. 1. pp. 94-108.
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