TY - JOUR
T1 - Regulation of Fasted Blood Glucose by Resistin
AU - Banerjee, Ronadip R.
AU - Rangwala, Shamina M.
AU - Shapiro, Jennifer S.
AU - Rich, A. Sophie
AU - Rhoades, Ben
AU - Qi, Yong
AU - Wang, Juan
AU - Rajala, Michael W.
AU - Pocai, Alessandro
AU - Scherer, Phillipp E.
AU - Steppan, Claire M.
AU - Ahima, Rexford S.
AU - Obici, Silvana
AU - Rossetti, Luciano
AU - Lazar, Mitchell A.
PY - 2004/2/20
Y1 - 2004/2/20
N2 - The association between obesity and diabetes supports an endocrine role for the adipocyte in maintaining glucose homeostasis. Here we report that mice lacking the adipocyte hormone resistin exhibit low blood glucose levels after fasting, due to reduced hepatic glucose production. This is partly mediated by activation of adenosine monophosphate-activated protein kinase and decreased expression of gluconeogenic enzymes in the liver. The data thus support a physiological function for resistin in the maintenance of blood glucose during fasting. Remarkably, lack of resistin diminishes the increase in post-fast blood glucose normally associated with increased weight, suggesting a role for resistin in mediating hyperglycemia associated with obesity.
AB - The association between obesity and diabetes supports an endocrine role for the adipocyte in maintaining glucose homeostasis. Here we report that mice lacking the adipocyte hormone resistin exhibit low blood glucose levels after fasting, due to reduced hepatic glucose production. This is partly mediated by activation of adenosine monophosphate-activated protein kinase and decreased expression of gluconeogenic enzymes in the liver. The data thus support a physiological function for resistin in the maintenance of blood glucose during fasting. Remarkably, lack of resistin diminishes the increase in post-fast blood glucose normally associated with increased weight, suggesting a role for resistin in mediating hyperglycemia associated with obesity.
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U2 - 10.1126/science.1092341
DO - 10.1126/science.1092341
M3 - Article
C2 - 14976316
AN - SCOPUS:10744225368
SN - 0036-8075
VL - 303
SP - 1195
EP - 1198
JO - Science
JF - Science
IS - 5661
ER -