Regulation of Fasted Blood Glucose by Resistin

Ronadip R. Banerjee, Shamina M. Rangwala, Jennifer S. Shapiro, A. Sophie Rich, Ben Rhoades, Yong Qi, Juan Wang, Michael W. Rajala, Alessandro Pocai, Phillipp E. Scherer, Claire M. Steppan, Rexford S. Ahima, Silvana Obici, Luciano Rossetti, Mitchell A. Lazar

Research output: Contribution to journalArticlepeer-review

590 Scopus citations

Abstract

The association between obesity and diabetes supports an endocrine role for the adipocyte in maintaining glucose homeostasis. Here we report that mice lacking the adipocyte hormone resistin exhibit low blood glucose levels after fasting, due to reduced hepatic glucose production. This is partly mediated by activation of adenosine monophosphate-activated protein kinase and decreased expression of gluconeogenic enzymes in the liver. The data thus support a physiological function for resistin in the maintenance of blood glucose during fasting. Remarkably, lack of resistin diminishes the increase in post-fast blood glucose normally associated with increased weight, suggesting a role for resistin in mediating hyperglycemia associated with obesity.

Original languageEnglish (US)
Pages (from-to)1195-1198
Number of pages4
JournalScience
Volume303
Issue number5661
DOIs
StatePublished - Feb 20 2004

ASJC Scopus subject areas

  • General

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