Regulation of Foxo-1 and the angiopoietin-2/Tie2 system by shear stress

Sven Chlench, Nigussie Mecha Disassa, Margret Hohberg, Christian Hoffmann, Theresa Pohlkamp, Gabriele Beyer, Mauro Bongrazio, Luis Da Silva-Azevedo, Oliver Baum, Axel Radlach Pries, Andreas Zakrzewicz

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Transcription factor Foxo-1 can be inactivated via Akt-mediated phosphorylation. Since shear stress activates Akt, we determined whether Foxo-1 and the Foxo-1-dependent, angiogenesis-related Ang-2/Tie2-system are influenced by shear stress in endothelial cells. Expression of Foxo-1 and its target genes p27Kip1 and Ang-2 was decreased under shear stress (6 dyn/cm2, 24 h), nuclear exclusion of Foxo-1 by phosphorylation increased. eNOS and Tie2 were upregulated. No effects on Ang-1 expression were detected. In conclusion, Foxo-1 and Ang-2/Tie2 are part of the molecular response to shear stress, which may regulate angiogenesis.

Original languageEnglish (US)
Pages (from-to)673-680
Number of pages8
JournalFEBS Letters
Volume581
Issue number4
DOIs
StatePublished - Feb 20 2007
Externally publishedYes

Keywords

  • Ang-2
  • Angiogenesis
  • Endothelium
  • Foxo-1
  • Shear stress
  • Tie2

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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