Regulation of hippocampal progenitor cell survival, proliferation and dendritic development by BDNF

Se Hoon Choi, Yun Li, Luis F. Parada, Sangram S. Sisodia

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Background. Environmental enrichment (EE) is known to enhance BDNF levels and neurogenesis in the adult hippocampus. To examine the role of BDNF in modulating EE-mediated adult hippocampal neurogenesis, we conditionally ablated BDNF expression in the hippocampus (cKO mice) and have assessed proliferation, survival, differentiation and dendritic development of hippocampal progenitors. Results. We show that while the extent of cell proliferation and neuronal fate differentiation in the hippocampus of cKO mice is not different from wild-type (WT) littermates maintained in either standard or enriched conditions, reduced BDNF levels significantly impaired the survival of newborn cells in both housing conditions. In addition, while highly active enriched WT mice exhibited a robust increase in progenitor cell proliferation, highly active cKO mice showed a modest increase in cell proliferation compared to standard housed or underactive cKO mice. Conclusions. There results argue that while BDNF plays a role in exercise-induced cell proliferation, other factors must contribute to this phenomenon. We also show that dendritic development was impaired in cKO mice maintained in standard housing conditions, and that EE rescued this phenotype.

Original languageEnglish (US)
Article number52
JournalMolecular Neurodegeneration
Volume4
Issue number1
DOIs
StatePublished - 2009

Fingerprint

Brain-Derived Neurotrophic Factor
Cell Survival
Stem Cells
Cell Proliferation
Hippocampus
Neurogenesis
Phenotype

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Clinical Neurology
  • Molecular Biology

Cite this

Regulation of hippocampal progenitor cell survival, proliferation and dendritic development by BDNF. / Choi, Se Hoon; Li, Yun; Parada, Luis F.; Sisodia, Sangram S.

In: Molecular Neurodegeneration, Vol. 4, No. 1, 52, 2009.

Research output: Contribution to journalArticle

Choi, Se Hoon ; Li, Yun ; Parada, Luis F. ; Sisodia, Sangram S. / Regulation of hippocampal progenitor cell survival, proliferation and dendritic development by BDNF. In: Molecular Neurodegeneration. 2009 ; Vol. 4, No. 1.
@article{a3dd44a005c14ada905ffc8bca137f9f,
title = "Regulation of hippocampal progenitor cell survival, proliferation and dendritic development by BDNF",
abstract = "Background. Environmental enrichment (EE) is known to enhance BDNF levels and neurogenesis in the adult hippocampus. To examine the role of BDNF in modulating EE-mediated adult hippocampal neurogenesis, we conditionally ablated BDNF expression in the hippocampus (cKO mice) and have assessed proliferation, survival, differentiation and dendritic development of hippocampal progenitors. Results. We show that while the extent of cell proliferation and neuronal fate differentiation in the hippocampus of cKO mice is not different from wild-type (WT) littermates maintained in either standard or enriched conditions, reduced BDNF levels significantly impaired the survival of newborn cells in both housing conditions. In addition, while highly active enriched WT mice exhibited a robust increase in progenitor cell proliferation, highly active cKO mice showed a modest increase in cell proliferation compared to standard housed or underactive cKO mice. Conclusions. There results argue that while BDNF plays a role in exercise-induced cell proliferation, other factors must contribute to this phenomenon. We also show that dendritic development was impaired in cKO mice maintained in standard housing conditions, and that EE rescued this phenotype.",
author = "Choi, {Se Hoon} and Yun Li and Parada, {Luis F.} and Sisodia, {Sangram S.}",
year = "2009",
doi = "10.1186/1750-1326-4-52",
language = "English (US)",
volume = "4",
journal = "Molecular Neurodegeneration",
issn = "1750-1326",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Regulation of hippocampal progenitor cell survival, proliferation and dendritic development by BDNF

AU - Choi, Se Hoon

AU - Li, Yun

AU - Parada, Luis F.

AU - Sisodia, Sangram S.

PY - 2009

Y1 - 2009

N2 - Background. Environmental enrichment (EE) is known to enhance BDNF levels and neurogenesis in the adult hippocampus. To examine the role of BDNF in modulating EE-mediated adult hippocampal neurogenesis, we conditionally ablated BDNF expression in the hippocampus (cKO mice) and have assessed proliferation, survival, differentiation and dendritic development of hippocampal progenitors. Results. We show that while the extent of cell proliferation and neuronal fate differentiation in the hippocampus of cKO mice is not different from wild-type (WT) littermates maintained in either standard or enriched conditions, reduced BDNF levels significantly impaired the survival of newborn cells in both housing conditions. In addition, while highly active enriched WT mice exhibited a robust increase in progenitor cell proliferation, highly active cKO mice showed a modest increase in cell proliferation compared to standard housed or underactive cKO mice. Conclusions. There results argue that while BDNF plays a role in exercise-induced cell proliferation, other factors must contribute to this phenomenon. We also show that dendritic development was impaired in cKO mice maintained in standard housing conditions, and that EE rescued this phenotype.

AB - Background. Environmental enrichment (EE) is known to enhance BDNF levels and neurogenesis in the adult hippocampus. To examine the role of BDNF in modulating EE-mediated adult hippocampal neurogenesis, we conditionally ablated BDNF expression in the hippocampus (cKO mice) and have assessed proliferation, survival, differentiation and dendritic development of hippocampal progenitors. Results. We show that while the extent of cell proliferation and neuronal fate differentiation in the hippocampus of cKO mice is not different from wild-type (WT) littermates maintained in either standard or enriched conditions, reduced BDNF levels significantly impaired the survival of newborn cells in both housing conditions. In addition, while highly active enriched WT mice exhibited a robust increase in progenitor cell proliferation, highly active cKO mice showed a modest increase in cell proliferation compared to standard housed or underactive cKO mice. Conclusions. There results argue that while BDNF plays a role in exercise-induced cell proliferation, other factors must contribute to this phenomenon. We also show that dendritic development was impaired in cKO mice maintained in standard housing conditions, and that EE rescued this phenotype.

UR - http://www.scopus.com/inward/record.url?scp=74849094086&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=74849094086&partnerID=8YFLogxK

U2 - 10.1186/1750-1326-4-52

DO - 10.1186/1750-1326-4-52

M3 - Article

VL - 4

JO - Molecular Neurodegeneration

JF - Molecular Neurodegeneration

SN - 1750-1326

IS - 1

M1 - 52

ER -