TY - JOUR
T1 - Regulation of hormone-sensitive renal phosphate transport
AU - Gattineni, Jyothsna
AU - Friedman, Peter A.
PY - 2015
Y1 - 2015
N2 - Phosphate is essential for growth and maintenance of the skeleton and for generating high-energy phosphate compounds. Evolutionary adaptation to high dietary phosphorous in humans and other terrestrial vertebrates involves regulated mechanisms assuring the efficient renal elimination of excess phosphate. These mechanisms prominently include PTH, FGF23, and Vitamin D, which directly and indirectly regulate phosphate transport. Disordered phosphate homeostasis is associated with pathologies ranging from kidney stones to kidney failure. Chronic kidney disease results in hyperphosphatemia, an elevated calcium-phosphate product with considerable morbidity and mortality, mostly associated with adverse cardiovascular events. This chapter highlights recent findings and insights regarding the hormonal regulation of renal phosphate transport along with imbalances of phosphate balance due to acquired or inherited diseases states.
AB - Phosphate is essential for growth and maintenance of the skeleton and for generating high-energy phosphate compounds. Evolutionary adaptation to high dietary phosphorous in humans and other terrestrial vertebrates involves regulated mechanisms assuring the efficient renal elimination of excess phosphate. These mechanisms prominently include PTH, FGF23, and Vitamin D, which directly and indirectly regulate phosphate transport. Disordered phosphate homeostasis is associated with pathologies ranging from kidney stones to kidney failure. Chronic kidney disease results in hyperphosphatemia, an elevated calcium-phosphate product with considerable morbidity and mortality, mostly associated with adverse cardiovascular events. This chapter highlights recent findings and insights regarding the hormonal regulation of renal phosphate transport along with imbalances of phosphate balance due to acquired or inherited diseases states.
UR - http://www.scopus.com/inward/record.url?scp=84955677910&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84955677910&partnerID=8YFLogxK
U2 - 10.1016/bs.vh.2015.01.002
DO - 10.1016/bs.vh.2015.01.002
M3 - Article
C2 - 25817872
AN - SCOPUS:84955677910
SN - 0083-6729
VL - 98
SP - 249
EP - 306
JO - Vitamins and Hormones
JF - Vitamins and Hormones
ER -