Regulation of intracellular signaling by extracellular glycan remodeling

Randy B. Parker, Jennifer J. Kohler

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

The plasma membrane of eukaryotic cells is coated with carbohydrates. By virtue of their extracellular position and recognizable chemical features, cell surface glycans mediate many receptor - ligand interactions. Recently, mammalian extracellular hydrolytic enzymes have been shown to modify the structure of cell surface glycans and consequently alter their binding properties. These cell surface glycan remodeling events can cause rapid changes in critical signal transduction phenomena. This Review highlights recent studies on the roles of eukaryotic extracellular sialidases, sulfatases, and a deacetylase in regulation of intracellular signaling. We also describe possible therapies that target extracellular glycan remodeling processes and discuss the potential for new discoveries in this area.

Original languageEnglish (US)
Pages (from-to)35-46
Number of pages12
JournalACS Chemical Biology
Volume5
Issue number1
DOIs
StatePublished - Jan 15 2010

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Polysaccharides
Sulfatases
Signal transduction
Eukaryotic Cells
Cell membranes
Signal Transduction
Carbohydrates
Cell Membrane
Ligands
Enzymes
Therapeutics

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine

Cite this

Regulation of intracellular signaling by extracellular glycan remodeling. / Parker, Randy B.; Kohler, Jennifer J.

In: ACS Chemical Biology, Vol. 5, No. 1, 15.01.2010, p. 35-46.

Research output: Contribution to journalArticle

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