Regulation of ion channels by secreted Klotho

Research output: Chapter in Book/Report/Conference proceedingChapter

16 Scopus citations

Abstract

Klotho is an anti-aging protein predominantly expressed in the kidney, parathyroid glands and choroid plexus of the brain. Klotho exists in two forms, a membrane form and a soluble secreted form. Recent studies show that the secreted Klotho possess sialidase activity and regulates several ion channels via the activity. Removal of terminal sialic acids from N-glycan chains of the epithelial Ca 2+ channel TRPV5 and the renal K + channel ROMK by secreted Klotho exposes the underlying disaccharide galactose-N- acetylglucosamine, a ligand for galectin-1. Binding to galectin-1 at the extracellular surface prevents internalization and leads to accumulation of the channels on the plasma membrane. Future studies will investigate whether secreted Klotho regulates cell-surface expression of other membrane glycoproteins via the same mechanism.

Original languageEnglish (US)
Title of host publicationEndocrine FGFs and Klothos
Pages100-106
Number of pages7
DOIs
StatePublished - Apr 19 2012

Publication series

NameAdvances in Experimental Medicine and Biology
Volume728
ISSN (Print)0065-2598

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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