@inbook{cd38e85856d743b6ab412ba4ac56ad6e,
title = "Regulation of ion channels by secreted Klotho",
abstract = "Klotho is an anti-aging protein predominantly expressed in the kidney, parathyroid glands and choroid plexus of the brain. Klotho exists in two forms, a membrane form and a soluble secreted form. Recent studies show that the secreted Klotho possess sialidase activity and regulates several ion channels via the activity. Removal of terminal sialic acids from N-glycan chains of the epithelial Ca 2+ channel TRPV5 and the renal K + channel ROMK by secreted Klotho exposes the underlying disaccharide galactose-N- acetylglucosamine, a ligand for galectin-1. Binding to galectin-1 at the extracellular surface prevents internalization and leads to accumulation of the channels on the plasma membrane. Future studies will investigate whether secreted Klotho regulates cell-surface expression of other membrane glycoproteins via the same mechanism.",
author = "Huang, {Chou Long}",
year = "2012",
month = apr,
day = "19",
doi = "10.1007/978-1-4614-0887-1_7",
language = "English (US)",
isbn = "9781461408864",
series = "Advances in Experimental Medicine and Biology",
pages = "100--106",
booktitle = "Endocrine FGFs and Klothos",
}