Regulation of ion channels by secreted Klotho

Research output: Chapter in Book/Report/Conference proceedingChapter

15 Citations (Scopus)

Abstract

Klotho is an anti-aging protein predominantly expressed in the kidney, parathyroid glands and choroid plexus of the brain. Klotho exists in two forms, a membrane form and a soluble secreted form. Recent studies show that the secreted Klotho possess sialidase activity and regulates several ion channels via the activity. Removal of terminal sialic acids from N-glycan chains of the epithelial Ca 2+ channel TRPV5 and the renal K + channel ROMK by secreted Klotho exposes the underlying disaccharide galactose-N- acetylglucosamine, a ligand for galectin-1. Binding to galectin-1 at the extracellular surface prevents internalization and leads to accumulation of the channels on the plasma membrane. Future studies will investigate whether secreted Klotho regulates cell-surface expression of other membrane glycoproteins via the same mechanism.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
Pages100-106
Number of pages7
Volume728
DOIs
StatePublished - 2012

Publication series

NameAdvances in Experimental Medicine and Biology
Volume728
ISSN (Print)00652598

Fingerprint

Galectin 1
Ion Channels
Sialic Acids
Kidney
Choroid Plexus
Parathyroid Glands
Acetylglucosamine
Disaccharides
Membrane Glycoproteins
Neuraminidase
Cell membranes
Galactose
Polysaccharides
Brain
Aging of materials
Cell Membrane
Ligands
Membranes
Proteins

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Huang, C. L. (2012). Regulation of ion channels by secreted Klotho. In Advances in Experimental Medicine and Biology (Vol. 728, pp. 100-106). (Advances in Experimental Medicine and Biology; Vol. 728). https://doi.org/10.1007/978-1-4614-0887-1_7

Regulation of ion channels by secreted Klotho. / Huang, Chou Long.

Advances in Experimental Medicine and Biology. Vol. 728 2012. p. 100-106 (Advances in Experimental Medicine and Biology; Vol. 728).

Research output: Chapter in Book/Report/Conference proceedingChapter

Huang, CL 2012, Regulation of ion channels by secreted Klotho. in Advances in Experimental Medicine and Biology. vol. 728, Advances in Experimental Medicine and Biology, vol. 728, pp. 100-106. https://doi.org/10.1007/978-1-4614-0887-1_7
Huang CL. Regulation of ion channels by secreted Klotho. In Advances in Experimental Medicine and Biology. Vol. 728. 2012. p. 100-106. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-1-4614-0887-1_7
Huang, Chou Long. / Regulation of ion channels by secreted Klotho. Advances in Experimental Medicine and Biology. Vol. 728 2012. pp. 100-106 (Advances in Experimental Medicine and Biology).
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