Regulation of ion channels by secreted Klotho: Mechanisms and implications

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Abstract

Klotho is an anti-aging protein predominantly expressed in the kidney, parathyroid glands, and choroid plexus of the brain. It is a single-pass transmembrane protein with a large extracellular domain. The extracellular domain of Klotho is cleaved and released into extracellular fluid, including blood, urine, and cerebrospinal fluid. The membrane-bound fulllength Klotho and secreted extracellular domain of Klotho have distinct functions. Membrane Klotho interacts with fibroblast growth factor (FGF) receptors to form high-affinity receptors for FGF23. Secreted Klotho functions as a humoral factor that regulates several ion channels and transporters, and other processes, including insulin and insulin-like growth factor signaling. This mini-review focuses on the mechanisms of regulation of cell-surface abundance of ion channels by secreted Klotho and the importance of these effects of Klotho in physiology and pathological conditions.

Original languageEnglish (US)
Pages (from-to)855-860
Number of pages6
JournalKidney International
Volume77
Issue number10
DOIs
Publication statusPublished - May 2010

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Keywords

  • Galectin
  • N-glycan
  • ROMK
  • Sialidase
  • TRPC6
  • TRPV5

ASJC Scopus subject areas

  • Nephrology

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