Abstract
Klotho is an anti-aging protein predominantly expressed in the kidney, parathyroid glands, and choroid plexus of the brain. It is a single-pass transmembrane protein with a large extracellular domain. The extracellular domain of Klotho is cleaved and released into extracellular fluid, including blood, urine, and cerebrospinal fluid. The membrane-bound fulllength Klotho and secreted extracellular domain of Klotho have distinct functions. Membrane Klotho interacts with fibroblast growth factor (FGF) receptors to form high-affinity receptors for FGF23. Secreted Klotho functions as a humoral factor that regulates several ion channels and transporters, and other processes, including insulin and insulin-like growth factor signaling. This mini-review focuses on the mechanisms of regulation of cell-surface abundance of ion channels by secreted Klotho and the importance of these effects of Klotho in physiology and pathological conditions.
Original language | English (US) |
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Pages (from-to) | 855-860 |
Number of pages | 6 |
Journal | Kidney international |
Volume | 77 |
Issue number | 10 |
DOIs | |
State | Published - May 2010 |
Keywords
- Galectin
- N-glycan
- ROMK
- Sialidase
- TRPC6
- TRPV5
ASJC Scopus subject areas
- Nephrology