Regulation of matrix metalloproteinase (MMP) activity by the low-density lipoprotein receptor-related protein (LRP). A new function for an "old friend"

Hervé Emonard, Georges Bellon, Philippe De Diesbach, Marcel Mettlen, William Hornebeck, Pierre J. Courtoy

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

Matrix metalloproteinases (MMPs) are essential contributors to a microenvironment that promotes tumour progression. During the two last decades, inhibition of MMPs has become the focus of considerable interest for cancer therapy, and numerous synthetic metalloproteinase inhibitors have been developed by the pharmaceutical industry. However, clinical trials have shown disappointing efficacy or unexpected toxicity and new targets are thus eagerly awaited. The identification of endocytic clearance of several MMPs by the low-density lipoprotein receptor-related protein (LRP) might provide insight into novel strategies for controlling MMP level during malignant processes. This review attempts to summarize recent aspects on the cellular and molecular basis of LRP-mediated endocytic disposal of MMPs.

Original languageEnglish (US)
Pages (from-to)369-376
Number of pages8
JournalBiochimie
Volume87
Issue number3-4 SPEC. ISS.
DOIs
StatePublished - Mar 2005

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Keywords

  • Endocytosis
  • Low-density lipoprotein receptor-related protein
  • Matrix metalloproteinase
  • Regulation

ASJC Scopus subject areas

  • Biochemistry

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