Regulation of mismatch repair by histone code and posttranslational modifications in eukaryotic cells

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

DNA mismatch repair (MMR) protects genome integrity by correcting DNA replication-associated mispairs, modulating DNA damage-induced cell cycle checkpoints and regulating homeologous recombination. Loss of MMR function leads to cancer development. This review describes progress in understanding how MMR is carried out in the context of chromatin and how chromatin organization/compaction, epigenetic mechanisms and posttranslational modifications of MMR proteins influence and regulate MMR in eukaryotic cells.

Original languageEnglish (US)
Pages (from-to)68-74
Number of pages7
JournalDNA repair
Volume38
DOIs
StatePublished - Feb 1 2016

Keywords

  • Deacetylase
  • H3K36me3
  • Histone methylation
  • MSH2
  • PCNA
  • Phosphorylation
  • Ubiquitination

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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