Regulation of mismatch repair by histone code and posttranslational modifications in eukaryotic cells

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

DNA mismatch repair (MMR) protects genome integrity by correcting DNA replication-associated mispairs, modulating DNA damage-induced cell cycle checkpoints and regulating homeologous recombination. Loss of MMR function leads to cancer development. This review describes progress in understanding how MMR is carried out in the context of chromatin and how chromatin organization/compaction, epigenetic mechanisms and posttranslational modifications of MMR proteins influence and regulate MMR in eukaryotic cells.

Original languageEnglish (US)
Pages (from-to)68-74
Number of pages7
JournalDNA Repair
Volume38
DOIs
StatePublished - Feb 1 2016

Fingerprint

Histone Code
DNA Mismatch Repair
Eukaryotic Cells
Post Translational Protein Processing
Histones
Repair
Chromatin
DNA
Cell Cycle Checkpoints
DNA Replication
Epigenomics
Genetic Recombination
DNA Damage
Compaction
Genes
Cells
Genome
Neoplasms
Proteins

Keywords

  • Deacetylase
  • H3K36me3
  • Histone methylation
  • MSH2
  • PCNA
  • Phosphorylation
  • Ubiquitination

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Regulation of mismatch repair by histone code and posttranslational modifications in eukaryotic cells. / Li, Feng; Ortega, Janice; Gu, Liya; Li, Guo Min.

In: DNA Repair, Vol. 38, 01.02.2016, p. 68-74.

Research output: Contribution to journalArticle

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