Abstract
The ability to control gene expression is central to normal development and function. For a growing number of genes in the central nervous system and peripheral tissues, expression is determined by changes in the rate of mRNA decay. At a molecular level, regulated interactions between the mRNA target and sequence-specific binding proteins either inhibit or accelerate decay, affording tight control over gene expression. This review discusses several examples of such posttranscriptional gene regulation.
Original language | English (US) |
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Pages (from-to) | 311-316 |
Number of pages | 6 |
Journal | Journal of Neuroscience Research |
Volume | 66 |
Issue number | 3 |
DOIs | |
State | Published - Nov 1 2001 |
Keywords
- Alzheimer's disease
- HuR
- Myelin
- mRNA
- mRNA binding proteins
- mRNA decay
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience