Regulation of mRNA stability in the nervous system and beyond

Research output: Contribution to journalShort survey

41 Scopus citations

Abstract

The ability to control gene expression is central to normal development and function. For a growing number of genes in the central nervous system and peripheral tissues, expression is determined by changes in the rate of mRNA decay. At a molecular level, regulated interactions between the mRNA target and sequence-specific binding proteins either inhibit or accelerate decay, affording tight control over gene expression. This review discusses several examples of such posttranscriptional gene regulation.

Original languageEnglish (US)
Pages (from-to)311-316
Number of pages6
JournalJournal of Neuroscience Research
Volume66
Issue number3
DOIs
StatePublished - Nov 1 2001

Keywords

  • Alzheimer's disease
  • HuR
  • Myelin
  • mRNA
  • mRNA binding proteins
  • mRNA decay

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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