Regulation of myoglobin expression

Shane B. Kanatous, Pradeep P A Mammen

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Myoglobin is a well-characterized, cytoplasmic hemoprotein that is expressed primarily in cardiomyocytes and oxidative skeletal muscle fibers. However, recent studies also suggest low-level myoglobin expression in various non-muscle tissues. Prior studies incorporating molecular, pharmacological, physiological and transgenic technologies have demonstrated that myoglobin is an essential oxygen-storage hemoprotein capable of facilitating oxygen transport and modulating nitric oxide homeostasis within cardiac and skeletal myocytes. Concomitant with these studies, scientific investigations into the transcriptional regulation of myoglobin expression have been undertaken. These studies have indicated that activation of key transcription factors (MEF2, NFAT and Sp1) and co-activators (PGC-1α) by locomotor activity, differential intracellular calcium fluxes and low intracellular oxygen tension collectively regulate myoglobin expression. Future studies focused on tissue-specific transcriptional regulatory pathways and post-translational modifications governing myoglobin expression will need to be undertaken. Finally, further studies investigating the modulation of myoglobin expression under various myopathic processes may identify myoglobin as a novel therapeutic target for the treatment of various cardiac and skeletal myopathies.

Original languageEnglish (US)
Pages (from-to)2741-2747
Number of pages7
JournalJournal of Experimental Biology
Volume213
Issue number16
DOIs
StatePublished - Aug 2010

Fingerprint

myoglobin
Myoglobin
oxygen
homeostasis
nitric oxide
Skeletal Muscle Fibers
muscle
Oxygen
calcium
Cardiac Myocytes
MEF2 Transcription Factors
Sp1 Transcription Factor
regulation
muscular diseases
post-translational modification
Muscular Diseases
Locomotion
Post Translational Protein Processing
locomotion
Nitric Oxide

Keywords

  • Calcineurin
  • Hypoxia
  • MEF2
  • Myoglobin
  • NFAT
  • PGC-1α
  • Transcriptional regulation
  • Transgenic mice

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Physiology
  • Insect Science
  • Aquatic Science
  • Medicine(all)

Cite this

Regulation of myoglobin expression. / Kanatous, Shane B.; Mammen, Pradeep P A.

In: Journal of Experimental Biology, Vol. 213, No. 16, 08.2010, p. 2741-2747.

Research output: Contribution to journalArticle

Kanatous, Shane B. ; Mammen, Pradeep P A. / Regulation of myoglobin expression. In: Journal of Experimental Biology. 2010 ; Vol. 213, No. 16. pp. 2741-2747.
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