Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex

Ryan S. Westphal, Steven J. Tavalin, Jerry W. Lin, Neal M. Alto, Iain D C Fraser, Lorene K. Langeberg, Morgan Sheng, John D. Scott

Research output: Contribution to journalArticle

407 Citations (Scopus)

Abstract

Regulation of N-methyl-D-aspartate (NMDA) receptor activity by kinases and phosphatases contributes to the modulation of synaptic transmission. Targeting of these enzymes near the substrate is proposed to enhance phosphorylation-dependent modulation. Yotiao, an MMDA receptor-associated protein, bound the type 1 protein phosphatase (PP1) and the adenosine 3',5'- monophosphate (cAMP)-dependent protein kinase (PKA) holoenzyme. Anchored PP1 was active, limiting channel activity, whereas PKA activation overcame constitutive PP1 activity and conferred rapid enhancement of MMDA receptor currents. Hence, yotiao is a scaffold protein that physically attaches PP1 and PKA to NMDA receptors to regulate channel activity.

Original languageEnglish (US)
Pages (from-to)93-96
Number of pages4
JournalScience
Volume285
Issue number5424
DOIs
StatePublished - Jul 2 1999

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N-Methyl-D-Aspartate Receptors
Phosphoric Monoester Hydrolases
Phosphotransferases
Protein Phosphatase 1
Holoenzymes
Cyclic AMP-Dependent Protein Kinases
Synaptic Transmission
Adenosine
Protein Kinases
Proteins
Phosphorylation
Enzymes
MMDA
protein kinase N

ASJC Scopus subject areas

  • General

Cite this

Westphal, R. S., Tavalin, S. J., Lin, J. W., Alto, N. M., Fraser, I. D. C., Langeberg, L. K., ... Scott, J. D. (1999). Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex. Science, 285(5424), 93-96. https://doi.org/10.1126/science.285.5424.93

Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex. / Westphal, Ryan S.; Tavalin, Steven J.; Lin, Jerry W.; Alto, Neal M.; Fraser, Iain D C; Langeberg, Lorene K.; Sheng, Morgan; Scott, John D.

In: Science, Vol. 285, No. 5424, 02.07.1999, p. 93-96.

Research output: Contribution to journalArticle

Westphal, RS, Tavalin, SJ, Lin, JW, Alto, NM, Fraser, IDC, Langeberg, LK, Sheng, M & Scott, JD 1999, 'Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex', Science, vol. 285, no. 5424, pp. 93-96. https://doi.org/10.1126/science.285.5424.93
Westphal RS, Tavalin SJ, Lin JW, Alto NM, Fraser IDC, Langeberg LK et al. Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex. Science. 1999 Jul 2;285(5424):93-96. https://doi.org/10.1126/science.285.5424.93
Westphal, Ryan S. ; Tavalin, Steven J. ; Lin, Jerry W. ; Alto, Neal M. ; Fraser, Iain D C ; Langeberg, Lorene K. ; Sheng, Morgan ; Scott, John D. / Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex. In: Science. 1999 ; Vol. 285, No. 5424. pp. 93-96.
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