Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex

Ryan S. Westphal, Steven J. Tavalin, Jerry W. Lin, Neal M. Alto, Iain D C Fraser, Lorene K. Langeberg, Morgan Sheng, John D. Scott

Research output: Contribution to journalArticle

411 Scopus citations

Abstract

Regulation of N-methyl-D-aspartate (NMDA) receptor activity by kinases and phosphatases contributes to the modulation of synaptic transmission. Targeting of these enzymes near the substrate is proposed to enhance phosphorylation-dependent modulation. Yotiao, an MMDA receptor-associated protein, bound the type 1 protein phosphatase (PP1) and the adenosine 3',5'- monophosphate (cAMP)-dependent protein kinase (PKA) holoenzyme. Anchored PP1 was active, limiting channel activity, whereas PKA activation overcame constitutive PP1 activity and conferred rapid enhancement of MMDA receptor currents. Hence, yotiao is a scaffold protein that physically attaches PP1 and PKA to NMDA receptors to regulate channel activity.

Original languageEnglish (US)
Pages (from-to)93-96
Number of pages4
JournalScience
Volume285
Issue number5424
DOIs
StatePublished - Jul 2 1999

ASJC Scopus subject areas

  • General

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    Westphal, R. S., Tavalin, S. J., Lin, J. W., Alto, N. M., Fraser, I. D. C., Langeberg, L. K., Sheng, M., & Scott, J. D. (1999). Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex. Science, 285(5424), 93-96. https://doi.org/10.1126/science.285.5424.93