Regulation of phospholipase C by G proteins

Paul C. Sternweis, Alan V. Smrcka

Research output: Contribution to journalReview articlepeer-review

174 Scopus citations


Specific phospholipase C enzymes can hydrolyse phosphatidylinositol 4,5-bisphosphate into two products: inositol 1,4,5-trisphosphate, which regulates the release of intracellular calcium stores, and diacylglycerol, which can stimulate protein kinase C. A new group of G proteins, the Gq subfamily, have recently been shown to mediate the regulation of this activity by a variety of hormones. How do different members of this family modulate unique phospholipase C isozymes? What is the mechanism of this regulation? How might the Gq subfamily act to modulate other important second messenger pathways? The tools to answer these questions are being rapidly developed.

Original languageEnglish (US)
Pages (from-to)502-506
Number of pages5
JournalTrends in Biochemical Sciences
Issue number12
StatePublished - Dec 1992

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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