TY - JOUR
T1 - Regulation of phospholipase C by G proteins
AU - Sternweis, Paul C.
AU - Smrcka, Alan V.
PY - 1992/12
Y1 - 1992/12
N2 - Specific phospholipase C enzymes can hydrolyse phosphatidylinositol 4,5-bisphosphate into two products: inositol 1,4,5-trisphosphate, which regulates the release of intracellular calcium stores, and diacylglycerol, which can stimulate protein kinase C. A new group of G proteins, the Gq subfamily, have recently been shown to mediate the regulation of this activity by a variety of hormones. How do different members of this family modulate unique phospholipase C isozymes? What is the mechanism of this regulation? How might the Gq subfamily act to modulate other important second messenger pathways? The tools to answer these questions are being rapidly developed.
AB - Specific phospholipase C enzymes can hydrolyse phosphatidylinositol 4,5-bisphosphate into two products: inositol 1,4,5-trisphosphate, which regulates the release of intracellular calcium stores, and diacylglycerol, which can stimulate protein kinase C. A new group of G proteins, the Gq subfamily, have recently been shown to mediate the regulation of this activity by a variety of hormones. How do different members of this family modulate unique phospholipase C isozymes? What is the mechanism of this regulation? How might the Gq subfamily act to modulate other important second messenger pathways? The tools to answer these questions are being rapidly developed.
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U2 - 10.1016/0968-0004(92)90340-F
DO - 10.1016/0968-0004(92)90340-F
M3 - Review article
C2 - 1335185
AN - SCOPUS:0026497385
SN - 0968-0004
VL - 17
SP - 502
EP - 506
JO - Trends in biochemical sciences
JF - Trends in biochemical sciences
IS - 12
ER -